Publication Name	World Journal of Gastroenterology
Manuscript ID	6906
Country	Czech Republic

Received	2013-10-29 20:48
Peer-Review Started	2013-11-01 15:06
To Make the First Decision	2013-12-26 11:04
Return for Revision	2013-12-27 21:12
Revised	2014-01-15 16:42
Second Decision	2014-02-20 09:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-02-20 09:25
Articles in Press	2014-05-23 10:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-27 17:39
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Experimental models of non-alcoholic fatty liver disease in rats
Manuscript Source	Invited Manuscript
All Author List	Otto Kucera and Zuzana Cervinkova
Funding Agency and Grant Number	Funding Agency Grant Number Programme PRVOUK P37/02
Corresponding Author	Otto Kucera, MD, PhD, Department of Physiology, Charles University in Prague, Faculty of Medicine in Hradec Kralove, Simkova 870, 50038 Hradec Kralove, Czech Republic. kucerao@lfhk.cuni.cz
Key Words	Animal model; High-fat diet; Methionine- and choline-deficient diet; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Otsuka-Long-Evans-Tokushima fatty rats; Zucker rats
Core Tip	Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, but its pathogenesis is still not fully understood. This paper reviews the commonly used experimental models of NAFLD in rats. We discuss nutritional, genetic and combined models of NAFLD, and we highlight their pros and cons with special emphasis on nutritional models. To date, there is not an ideal model that reflects all aspects of the complex etiopathogenesis of human NAFLD and the typical histological features of its different stages.
Publish Date	2014-07-14 17:39
Citation	Kucera O, Cervinkova Z. Experimental models of non-alcoholic fatty liver disease in rats. World J Gastroenterol 2014; 20(26): 8364-8376
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8364.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8364

Full Article (PDF)	WJG-20-8364.pdf
Full Article (Word)	WJG-20-8364.doc
Manuscript File	6906-Review.docx
Answering Reviewers	6906-Answering reviewers.pdf
Copyright License Agreement	6906-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6906-Language certificate.pdf
Peer-review Report	6906-Peer review(s).pdf
Scientific Editor Work List	6906-Scientific editor work list.doc