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11/30/2021 9:35:11 AM | Browse: 90 | Download: 155
Publication Name World Journal of Clinical Cases
Manuscript ID 69962
Country/Territory China
Received
2021-07-20 15:45
Peer-Review Started
2021-07-20 15:50
To Make the First Decision
Return for Revision
2021-08-10 15:27
Revised
2021-08-24 15:53
Second Decision
2021-10-18 06:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-10-18 09:18
Articles in Press
2021-10-18 09:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-09-24 09:07
Typeset the Manuscript
2021-11-18 03:21
Publish the Manuscript Online
2021-11-30 09:35
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation, normal T-cell expressed and secreted
Manuscript Source Unsolicited Manuscript
All Author List Shi-Hao Mao, Dan-Dan Feng, Xi Wang, Yi-Hui Zhi, Shu Lei, Xi Xing, Rong-Lin Jiang and Jian-Nong Wu
ORCID
Author(s) ORCID Number
Shi-Hao Mao http://orcid.org/0000-0002-0060-6286
Dan-Dan Feng http://orcid.org/0000-0002-0014-6929
Xi Wang http://orcid.org/0000-0003-4861-0441
Yi-Hui Zhi http://orcid.org/0000-0002-0106-2276
Shu Lei http://orcid.org/0000-0002-0036-7879
Xi Xing http://orcid.org/0000-0002-9491-7084
Rong-Lin Jiang http://orcid.org/0000-0002-3821-0228
Jian-Nong Wu http://orcid.org/0000-0001-8867-9860
Funding Agency and Grant Number
Funding Agency Grant Number
Basic Public Welfare Research Foundation of Zhejiang Province, China GD21H290001
Traditional Chinese Medicine Science and Technology Project Foundation of Zhejiang Province, China 2020ZB072
Corresponding Author Jian-Nong Wu, MD, Chief Physician, Department of Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Post Road, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. 13777571598@163.com
Key Words Sepsis; Magnolol; Regulated on activation, normal T-cell expressed and secreted; Anti-inflammation; Lipopolysaccharide; Nuclear factor-kappa B
Core Tip In this study, it was found that magnolol inhibited the lipopolysaccharide-induced nuclear factor-kappa B signaling pathway in the intestinal mucosal epithelium to regulate the secretion of regulated on activation, normal T-cell expressed and secreted (RANTES) and thus reduce intestinal inflammation in sepsis. Various biological constituents, isolated from traditional Chinese medicine, show multifunctional activities. Magnolol, isolated from Magnolia, has been documented to possess a range of biological activities. The current results for the first time proved that magnolol plays a role in the treatment of sepsis by down-regulating RANTES. Thus, additional studies on its anti-inflammatory mechanism might provide novel ideas and methods for the clinical prevention and treatment of sepsis.
Publish Date 2021-11-30 09:35
Citation Mao SH, Feng DD, Wang X, Zhi YH, Lei S, Xing X, Jiang RL, Wu JN. Magnolol protects against acute gastrointestinal injury in sepsis by down-regulating regulated on activation, normal T-cell expressed and secreted. World J Clin Cases 2021; 9(34): 10451-10463
URL https://www.wjgnet.com/2307-8960/full/v9/i34/10451.htm
DOI https://dx.doi.org/10.12998/wjcc.v9.i34.10451
Full Article (PDF) WJCC-9-10451.pdf
Full Article (Word) WJCC-9-10451.docx
Manuscript File 69962_Auto_Edited-CCG-WangTQ.docx
Answering Reviewers 69962-Answering reviewers.pdf
Audio Core Tip 69962-Audio core tip.mp3
Biostatistics Review Certificate 69962-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 69962-Conflict-of-interest statement.pdf
Copyright License Agreement 69962-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 69962-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 69962-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 69962-Language certificate.pdf
Peer-review Report 69962-Peer-review(s).pdf
Scientific Editor Work List 69962-Scientific editor work list.pdf