Publication Name	World Journal of Psychiatry
Manuscript ID	70886
Country	Norway

Received	2021-09-22 10:52
Peer-Review Started	2021-09-22 10:55
To Make the First Decision
Return for Revision	2021-11-08 03:32
Revised	2021-12-14 12:45
Second Decision	2022-01-28 03:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-29 07:20
Articles in Press	2022-01-29 07:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-03-09 01:58
Publish the Manuscript Online	2022-03-18 12:26

ISSN	2220-3206 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Psychiatry
Manuscript Type	Prospective Study
Article Title	Trajectories of response in schizophrenia-spectrum disorders: A one-year prospective cohort study of antipsychotic effectiveness
Manuscript Source	Unsolicited Manuscript
All Author List	Petros Drosos, Erik Johnsen, Christoffer Andreas Bartz-Johannessen, Tor Ketil Larsen, Solveig Klæbo Reitan, Maria Rettenbacher and Rune Andreas Kroken
ORCID	Author(s) ORCID Number Petros Drosos http://orcid.org/0000-0002-3532-7367 Erik Johnsen http://orcid.org/0000-0003-0792-4436 Christoffer Andreas Bartz-Johannessen http://orcid.org/0000-0002-9615-4551 Tor Ketil Larsen http://orcid.org/0000-0001-7521-3834 Solveig Klæbo Reitan http://orcid.org/0000-0002-3469-6822 Maria Rettenbacher http://orcid.org/0000-0001-6544-2828 Rune Andreas Kroken http://orcid.org/0000-0002-0903-3840
Funding Agency and Grant Number	Funding Agency Grant Number Drosos P is a Research Fellow with a Grant From the Western Norway Regional Health Trust 912140
Corresponding Author	Petros Drosos, MD, Doctor, Research Fellow, TIPS-Network for Clinical Research in Psychosis, Clinic For Adult Mental Health, Stavanger University Hospital, Jan Johnsens Gate 12, Stavanger 4011, Norway. petros.drosos@sus.no
Key Words	Schizophrenia; Response; Trajectories; Treatment; Antipsychotic drugs
Core Tip	In this clinical trial of the three atypical antipsychotics amisulpride, aripiprazole, and olanzapine, we identified three trajectory groups of responses at the one-year follow-up. The majority of the study participants (87%) followed a trajectory of a good or strong response to antipsychotic drugs, while 13% showed a poor response. The use of amisulpride predicted belonging to the Strong response group. This antipsychotic should therefore be used more often in clinical practice. Unemployment, depression, and negative psychotic symptoms at baseline predicted nonresponse to antipsychotic drugs.
Publish Date	2022-03-18 12:26
Citation	Drosos P, Johnsen E, Bartz-Johannessen CA, Larsen TK, Reitan SK, Rettenbacher M, Kroken RA. Trajectories of response in schizophrenia-spectrum disorders: A one-year prospective cohort study of antipsychotic effectiveness. World J Psychiatr 2022; 12(3): 521-532
URL	https://www.wjgnet.com/2220-3206/full/v12/i3/521.htm
DOI	https://dx.doi.org/10.5498/wjp.v12.i3.521

Full Article (PDF)	WJP-12-521.pdf
Full Article (Word)	WJP-12-521.docx
CONSORT 2010 Statement	70886-CONSORT-2010-Statement-revision.pdf
Manuscript File	70886_Auto_Edited.docx
Answering Reviewers	70886-Answering reviewers.pdf
Audio Core Tip	70886-Audio core tip.mp3
Biostatistics Review Certificate	70886-Biostatistics statement.pdf
Clinical Trial Registration Statement	70886-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	70886-Conflict-of-interest statement.pdf
Copyright License Agreement	70886-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	70886-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	70886-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	70886-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	70886-Language certificate.pdf
Peer-review Report	70886-Peer-review(s).pdf
Scientific Misconduct Check	70886-Bing-Fan JR-2.png
Scientific Editor Work List	70886-Scientific editor work list.pdf