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8/3/2022 7:54:39 AM | Browse: 18 | Download: 33
Publication Name World Journal of Gastroenterology
Manuscript ID 71686
Country/Territory China
Received
2021-09-18 01:33
Peer-Review Started
2021-09-18 01:35
To Make the First Decision
Return for Revision
2021-12-04 07:23
Revised
2021-12-15 15:38
Second Decision
2022-07-06 08:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-11 18:39
Articles in Press
2022-07-11 18:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-25 02:48
Publish the Manuscript Online
2022-08-03 07:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Integrative and Complementary Medicine
Manuscript Type Basic Study
Article Title Qingyi decoction attenuates intestinal epithelial cell injury via the calcineurin/nuclear factor of activated T-cells pathway
Manuscript Source Unsolicited Manuscript
All Author List Guan-Yu Wang, Dong Shang, Gui-Xin Zhang, Hui-Yi Song, Nan Jiang, Huan-Huan Liu and Hai-Long Chen
ORCID
Author(s) ORCID Number
Guan-Yu Wang http://orcid.org/0000-0002-9982-8785
Dong Shang http://orcid.org/0000-0001-6156-5214
Gui-Xin Zhang http://orcid.org/0000-0003-0125-6609
Hui-Yi Song http://orcid.org/0000-0003-3415-9223
Nan Jiang http://orcid.org/0000-0002-0613-5729
Huan-Huan Liu http://orcid.org/0000-0002-2023-8708
Hai-Long Chen http://orcid.org/0000-0001-5547-5837
Funding Agency and Grant Number
Funding Agency Grant Number
National Key R and D Program of China 2019YFE0119300
National Natural Science Foundation of China 82074158
Project funded by China Postdoctoral Science Foundation 2018M631793
Natural Science Foundation of Liaoning Province 2019-ZD-0624
Dalian Traditional Chinese Medicine-Related Scientific Research Project 18Z2002
Corresponding Author Hai-Long Chen, PhD, Chief Physician, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. hailongchen2014@yeah.net
Key Words Severe acute pancreatitis; Intestinal epithelial cell; Apoptosis; Calcineurin/nuclear factor of activated T-cells pathway; Qingyi decoction
Core Tip This manuscript investigated the role of the calcineurin (CaN)/nuclear factor of activated T-cells (NFATc3) pathway in the apoptosis of intestinal epithelial cells (IECs) in severe acute pancreatitis (SAP) and the potential mechanisms underlying the therapeutic effect of Qingyi decoction (QYD). QYD significantly restrained CaN and NFATc3 gene expression in the intestine, ameliorated IEC apoptosis associated with SAP, and decreased the lipopolysaccharide-induced elevation in intracellular free Ca2+ levels and cell death. These findings suggest that the protective effects of QYD might be mediated, at least partially, by downregulating IEC apoptosis via the CaN/NFATc3 pathway.
Publish Date 2022-08-03 07:54
Citation Wang GY, Shang D, Zhang GX, Song HY, Jiang N, Liu HH, Chen HL. Qingyi decoction attenuates intestinal epithelial cell injury via the calcineurin/nuclear factor of activated T-cells pathway. World J Gastroenterol 2022; 28(29): 3825-3837
URL https://www.wjgnet.com/1007-9327/full/v28/i29/3825.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i29.3825
Full Article (PDF) WJG-28-3825.pdf
Full Article (Word) WJG-28-3825.docx
Manuscript File 71686_Auto_Edited-LS.docx
Answering Reviewers 71686-Answering reviewers.pdf
Audio Core Tip 71686-Audio core tip.mp3
Biostatistics Review Certificate 71686-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 71686-Conflict-of-interest statement.pdf
Copyright License Agreement 71686-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 71686-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 71686-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 71686-Language certificate.pdf
Peer-review Report 71686-Peer-review(s).pdf
Scientific Misconduct Check 71686-Bing-Wang JJ-2.png
Scientific Editor Work List 71686-Scientific editor work list.pdf