Publication Name	World Journal of Stem Cells
Manuscript ID	72372
Country	China

Received	2021-10-13 15:33
Peer-Review Started	2021-10-13 15:34
To Make the First Decision
Return for Revision	2021-11-08 03:17
Revised	2021-11-29 14:36
Second Decision	2022-01-24 03:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-25 03:18
Articles in Press	2022-01-25 03:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-22 01:42
Publish the Manuscript Online	2022-02-25 12:19

ISSN	1948-0210 (online)
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Yu Mao, Tian-Tian Zhang, Dong-Jiu Li, En Zhou, Yu-Qi Fan, Qing He, Chang-Qian Wang and Jun-Feng Zhang
ORCID	Author(s) ORCID Number Cheng-Yu Mao http://orcid.org/0000-0001-9740-8835 Tian-Tian Zhang http://orcid.org/0000-0001-8218-2757 Dong-Jiu Li http://orcid.org/0000-0003-4372-6613 En Zhou http://orcid.org/0000-0002-6073-8037 Yu-Qi Fan http://orcid.org/0000-0002-0084-2895 Qing He http://orcid.org/0000-0002-1078-350X Chang-Qian Wang http://orcid.org/0000-0002-7611-7761 Jun-Feng Zhang http://orcid.org/0000-0001-9530-3263
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81870264 National Natural Science Foundation of China 81470546 the Shanghai Committee of Science and Technology 18411950500 the Major Disease Joint Project of Shanghai Health System 2014ZYJB0501 Talent Cultivation Project of The Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine JC202005
Corresponding Author	Jun-Feng Zhang, MD, PhD, Professor, Department of Cardiology, Shanghai Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine, No. 280 Mohe Road, Baoshan District, Shanghai 200010, China. junfengzhang9hos@163.com
Key Words	Extracellular vesicles; Myocardial infarction; Mesenchymal stem cells; Hypoxia preconditioning; Thioredoxin-interacting protein; Hypoxia-inducible factor 1 alpha
Core Tip	Extracellular vesicles (EVs) from adipose-derived mesenchymal stem cells treated with hypoxia preconditioning improve tolerance toward myocardial infarction or hypoxic conditions and alleviate the degree of cardiomyocyte apoptosis until reperfusion therapy. The anti-apoptotic effects may result from EV miR-224-5p targeting thioredoxin-interacting protein (TXNIP) and subsequent TXNIP-mediated hypoxia-inducible factor-1 alpha ubiquitination and degradation via the chromosomal region maintenance-1-mediated nuclear transport pathway.
Publish Date	2022-02-25 12:19
Citation	Mao CY, Zhang TT, Li DJ, Zhou E, Fan YQ, He Q, Wang CQ, Zhang JF. Extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells alleviates myocardial injury by targeting thioredoxin-interacting protein-mediated hypoxia-inducible factor-1α pathway. World J Stem Cells 2022; 14(2): 183-199
URL	https://www.wjgnet.com/1948-0210/full/v14/i2/183.htm
DOI	https://dx.doi.org/10.4252/wjsc.v14.i2.183

Full Article (PDF)	WJSC-14-183.pdf
Full Article (Word)	WJSC-14-183.docx
Manuscript File	72372_Auto_Edited.docx
Answering Reviewers	72372-Answering reviewers.pdf
Audio Core Tip	72372-Audio core tip.mp3
Biostatistics Review Certificate	72372-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	72372-Conflict-of-interest statement.pdf
Copyright License Agreement	72372-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	72372-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	72372-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	72372-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	72372-Language certificate.pdf
Peer-review Report	72372-Peer-review(s).pdf
Scientific Misconduct Check	72372-Bing-Fan JR-2.png
Scientific Editor Work List	72372-Scientific editor work list.pdf