BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
11/24/2015 3:55:00 PM | Browse: 577 | Download: 757
Publication Name World Journal of Gastroenterology
Manuscript ID 7306
Country/Territory Pakistan
Received
2013-11-13 08:05
Peer-Review Started
2013-11-14 09:37
To Make the First Decision
2013-12-16 17:13
Return for Revision
2013-12-17 14:18
Revised
2014-02-21 19:59
Second Decision
2014-05-14 09:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-14 09:41
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-10-15 15:07
Typeset the Manuscript
2015-10-27 09:34
Publish the Manuscript Online
2015-11-18 12:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Basic Study
Article Title Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis
Manuscript Source Invited Manuscript
All Author List Fahed Parvaiz, Sobia Manzoor, Jawed Iqbal, Mehuli Sarkar-Dutta, Muhammad Imran and Gulam Waris
Funding Agency and Grant Number
Corresponding Author Sobia Manzoor, PhD, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, H-12, Islamabad 44000, Pakistan. lcianunique@yahoo.com
Key Words Hepatitis C virus nonstructural protein 5A; Insulin resistance; Forkhead box protein 01; Glycogen synthase kinase-beta; Gluconeogenesis
Core Tip The underlying molecular mechanisms of insulin resistance in response to hepatitis C virus (HCV) infection are poorly understood. Previous studies have demonstrated the effect of HCV core and envelop proteins on insulin signaling in human hepatocytes. However, the role of HCV nonstructural protein 5A (NS5A) in insulin resistance is not known. Our data clearly indicate the role of NS5A in insulin resistance through increased phosphorylation of IRS-1Ser307 and decreased phosphorylation of AktThr308, Fox01Ser256, and GSK3βSer9.
Publish Date 2015-11-18 12:39
Citation Parvaiz F, Manzoor S, Iqbal J, Sarkar-Dutta M, Imran M, Waris G. Hepatitis C virus NS5A promotes insulin resistance through IRS-1 serine phosphorylation and increased gluconeogenesis. World J Gastroenterol 2015; 21(43): 12361-12369
Url http://www.wjgnet.com/1007-9327/full/v21/i43/12361.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i43.12361
Full Article (PDF) WJG-21-12361.pdf
Full Article (Word) WJG-21-12361.doc
Manuscript File 7306-Review.docx
Answering Reviewers 7306-Answering reviewers.pdf
Copyright License Agreement 7306-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 7306-Language certificate.pdf
Peer-review Report 7306-Peer reviews.pdf
Scientific Editor Work List 7306-Scientific editor work list.pdf