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6/10/2022 2:05:28 AM | Browse: 266 | Download: 445
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 74252
Country/Territory China
Received
2021-12-18 06:20
Peer-Review Started
2021-12-18 06:22
To Make the First Decision
Return for Revision
2022-04-17 19:18
Revised
2022-04-22 16:06
Second Decision
2022-05-20 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-23 00:45
Articles in Press
2022-05-23 00:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-05-19 12:04
Typeset the Manuscript
2022-06-07 03:20
Publish the Manuscript Online
2022-06-10 02:05
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis
Manuscript Source Unsolicited Manuscript
All Author List Wei Wang, Meng-Nan Guo, Ning Li, De-Quan Pang and Jing-Hua Wu
ORCID
Author(s) ORCID Number
Wei Wang http://orcid.org/0000-0002-7863-8309
Meng-Nan Guo http://orcid.org/0000-0003-0694-7919
Ning Li http://orcid.org/0000-0002-4972-5841
De-Quan Pang http://orcid.org/0000-0001-7992-3649
Jing-Hua Wu http://orcid.org/0000-0002-2829-3496
Funding Agency and Grant Number
Funding Agency Grant Number
High-End Talent Funding Project in Hebei Province A202003005
Hebei Provincial Health Commission Office G2019074
Natural Science Foundation of Hebei Province H2019209355
Corresponding Author Jing-Hua Wu, MD, PhD, Chief Technician, Professor, Department of Laboratory Medicine, Tangshan Maternal and Child Health Care Hospital, North China University of Science and Technology, No. 1 Hetai Road, Lunan District, Tangshan 063000, Hebei Province, China. tswujinghua@163.com
Key Words Glutamine; Mitochondrial damage; CD8+ T cells; T cell function; Hepatocellular carcinoma
Core Tip This study aimed to investigate whether and how glutamine metabolism affects the function of infiltrating CD8+ T cells in hepatocellular carcinoma. Experimental validation was performed by using liver cancer tissues and cell lines. We discovered that glutamine deprivation impaired the function of infiltrating CD8+ T cells in hepatocellular carcinoma through the mitochondrial damage and apoptotic pathways.
Publish Date 2022-06-10 02:05
Citation Wang W, Guo MN, Li N, Pang DQ, Wu JH. Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis. World J Gastrointest Oncol 2022; 14(6): 1124-1140
URL https://www.wjgnet.com/1948-5204/full/v14/i6/1124.htm
DOI https://dx.doi.org/10.4251/wjgo.v14.i6.1124
Full Article (PDF) WJGO-14-1124.pdf
Full Article (Word) WJGO-14-1124.docx
Manuscript File 74252_Auto_Edited-CCG-Wang TQ-LS.docx
Answering Reviewers 74252-Answering reviewers.pdf
Audio Core Tip 74252-Audio core tip.mp3
Biostatistics Review Certificate 74252-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 74252-Conflict-of-interest statement.pdf
Copyright License Agreement 74252-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 74252-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 74252-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 74252-Language certificate.pdf
Peer-review Report 74252-Peer-review(s).pdf
Scientific Misconduct Check 74252-Bing-Gao CC-2.png
Scientific Editor Work List 74252-Scientific editor work list.pdf