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8/3/2022 7:54:39 AM | Browse: 14 | Download: 30
Publication Name World Journal of Gastroenterology
Manuscript ID 74962
Country/Territory Serbia
Received
2022-01-13 10:37
Peer-Review Started
2022-01-13 10:38
To Make the First Decision
Return for Revision
2022-05-29 07:59
Revised
2022-06-07 15:14
Second Decision
2022-06-29 03:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-06 14:22
Articles in Press
2022-07-06 14:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-25 02:37
Publish the Manuscript Online
2022-08-03 07:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Minireviews
Article Title Structural changes of proteins in liver cirrhosis and consequential changes in their function
Manuscript Source Invited Manuscript
All Author List Nikola Gligorijević, Simeon Minić and Olgica Nedić
ORCID
Author(s) ORCID Number
Nikola Gligorijević http://orcid.org/0000-0002-8691-2486
Simeon Minić http://orcid.org/0000-0002-7053-1216
Olgica Nedić http://orcid.org/0000-0003-2042-0056
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Science and Technological Development of the Republic of Serbia 451-03-9/2021-14/200019
Corresponding Author Nikola Gligorijević, PhD, Research Associate, Department of Metabolism, University of Belgrade-Institute for the Application of Nuclear Energy, Banatska 31b, Belgrade 11080, Serbia. nikolag@inep.co.rs
Key Words Liver cirrhosis; Post-translational modifications; Circulation; Protein function; Protein structure; Chronic liver disease
Core Tip Chronic liver diseases and cirrhosis are accompanied by various metabolic disorders, some of which affect proteins. Besides changes in the concentration, structural alterations of proteins occur, mostly at the level of posttranslational modifications (PTMs). Five frequent cirrhosis-related PTMs are oxidation, nitration, glycosylation, acetylation, and ubiquitination. Some are more specific for the circulating proteins, whereas others are more specific for liver tissue-residing proteins. PTMs influence folding, stability, half-life, aggregation, and function of proteins. Modified proteins with altered function contribute to further progression of liver pathology. An overview of cirrhosis-related alterations of PTMs of specific proteins is the topic of this article.
Publish Date 2022-08-03 07:54
Citation Gligorijević N, Minić S, Nedić O. Structural changes of proteins in liver cirrhosis and consequential changes in their function. World J Gastroenterol 2022; 28(29): 3780-3792
URL https://www.wjgnet.com/1007-9327/full/v28/i29/3780.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i29.3780
Full Article (PDF) WJG-28-3780.pdf
Full Article (Word) WJG-28-3780.docx
Manuscript File 74962_Auto_Edited-LM.docx
Answering Reviewers 74962-Answering reviewers.pdf
Audio Core Tip 74962-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 74962-Conflict-of-interest statement.pdf
Copyright License Agreement 74962-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 74962-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 74962-Language certificate.pdf
Peer-review Report 74962-Peer-review(s).pdf
Scientific Misconduct Check 74962-Bing-Wu YXJ-2.png
Scientific Editor Work List 74962-Scientific editor work list.pdf