Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	75201
Country	China

Received	2022-01-20 10:33
Peer-Review Started	2022-01-20 10:34
To Make the First Decision
Return for Revision	2022-04-12 01:56
Revised	2022-04-22 08:36
Second Decision	2022-08-22 03:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-25 21:02
Articles in Press	2022-08-25 21:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-08-08 13:51
Typeset the Manuscript	2022-09-16 08:07
Publish the Manuscript Online	2022-09-22 12:23

ISSN	1948-9366 (online)
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Category	Immunology
Manuscript Type	Observational Study
Article Title	Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Wang, Zhen-Feng Deng, Ji-Long Wang, Ling Zhang, Li Bao, Bang-Hao Xu, Hai Zhu, Ya Guo and Zhang Wen
ORCID	Author(s) ORCID Number Wei Wang http://orcid.org/0000-0001-5742-0645 Zhen-Feng Deng http://orcid.org/0000-0001-5226-9392 Ji-Long Wang http://orcid.org/0000-0001-7626-7199 Ling Zhang http://orcid.org/0000-0001-7542-1879 Li Bao http://orcid.org/0000-0003-4735-9021 Bang-Hao Xu http://orcid.org/0000-0001-7270-3504 Hai Zhu http://orcid.org/0000-0003-3697-984X Ya Guo http://orcid.org/0000-0003-0393-7045 Zhang Wen http://orcid.org/0000-0003-4268-540X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 8190111624 Guangxi Natural Science Foundation of China 2018JJB140382 Guangxi University Young and Middle-Aged Teachers’ Basic Scientific Research Ability Improvement Project 2019KY0123
Corresponding Author	Zhang Wen, MD, PhD, Chief Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6, Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wenzgxmu@163.com
Key Words	Associating liver partition and portal vein ligation for staged hepatectomy; Tumor-infiltrating lymphocytes; Multiplexed immunohistochemistry; Tumor necrosis
Core Tip	This study was conducted to evaluate the feasibility of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for massive hepatocellular carcinoma by exploring the role of tumor-infiltrating lymphocyte (TIL) subpopulations in the tumor microenvironment. The ALPPS procedure did not cause severe immunosuppression due to reduced TIL infiltration and pathological alterations in peripheral blood immune components. In addition, high perioperative CD8+ T cell infiltration with ALPPS was associated with increased tumor necrosis.
Publish Date	2022-09-22 12:23
Citation	Wang W, Deng ZF, Wang JL, Zhang L, Bao L, Xu BH, Zhu H, Guo Y, Wen Z. Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma. World J Gastrointest Surg 2022; 14(9): 1008-1025
URL	https://www.wjgnet.com/1948-9366/full/v14/i9/1008.htm
DOI	https://dx.doi.org/10.4240/wjgs.v14.i9.1008

Full Article (PDF)	WJGS-14-1008.pdf
Full Article (Word)	WJGS-14-1008.docx
STROBE Statement	75201-STROBE-Statement-revision.pdf
Manuscript File	75201_Auto_Edited-JJW-WangTQ-LS.docx
Answering Reviewers	75201-Answering reviewers.pdf
Audio Core Tip	75201-Audio core tip.m4a
Biostatistics Review Certificate	75201-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	75201-Conflict-of-interest statement.pdf
Copyright License Agreement	75201-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	75201-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	75201-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	75201-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	75201-Language certificate.pdf
Peer-review Report	75201-Peer-review(s).pdf
Scientific Misconduct Check	75201-Bing-Wang JJ-2.png
Scientific Editor Work List	75201-Scientific editor work list.pdf