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9/22/2022 12:23:56 PM | Browse: 11 | Download: 15
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 75201
Country/Territory China
Received
2022-01-20 10:33
Peer-Review Started
2022-01-20 10:34
To Make the First Decision
Return for Revision
2022-04-12 01:56
Revised
2022-04-22 08:36
Second Decision
2022-08-22 03:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-25 21:02
Articles in Press
2022-08-25 21:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-08-08 13:51
Typeset the Manuscript
2022-09-16 08:07
Publish the Manuscript Online
2022-09-22 12:23
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Observational Study
Article Title Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Wei Wang, Zhen-Feng Deng, Ji-Long Wang, Ling Zhang, Li Bao, Bang-Hao Xu, Hai Zhu, Ya Guo and Zhang Wen
ORCID
Author(s) ORCID Number
Wei Wang http://orcid.org/0000-0001-5742-0645
Zhen-Feng Deng http://orcid.org/0000-0001-5226-9392
Ji-Long Wang http://orcid.org/0000-0001-7626-7199
Ling Zhang http://orcid.org/0000-0001-7542-1879
Li Bao http://orcid.org/0000-0003-4735-9021
Bang-Hao Xu http://orcid.org/0000-0001-7270-3504
Hai Zhu http://orcid.org/0000-0003-3697-984X
Ya Guo http://orcid.org/0000-0003-0393-7045
Zhang Wen http://orcid.org/0000-0003-4268-540X
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 8190111624
Guangxi Natural Science Foundation of China 2018JJB140382
Guangxi University Young and Middle-Aged Teachers’ Basic Scientific Research Ability Improvement Project 2019KY0123
Corresponding Author Zhang Wen, MD, PhD, Chief Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6, Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. wenzgxmu@163.com
Key Words Associating liver partition and portal vein ligation for staged hepatectomy; Tumor-infiltrating lymphocytes; Multiplexed immunohistochemistry; Tumor necrosis
Core Tip This study was conducted to evaluate the feasibility of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) for massive hepatocellular carcinoma by exploring the role of tumor-infiltrating lymphocyte (TIL) subpopulations in the tumor microenvironment. The ALPPS procedure did not cause severe immunosuppression due to reduced TIL infiltration and pathological alterations in peripheral blood immune components. In addition, high perioperative CD8+ T cell infiltration with ALPPS was associated with increased tumor necrosis.
Publish Date 2022-09-22 12:23
Citation Wang W, Deng ZF, Wang JL, Zhang L, Bao L, Xu BH, Zhu H, Guo Y, Wen Z. Change of tumor-infiltrating lymphocyte of associating liver partition and portal vein ligation for staged hepatectomy for hepatocellular carcinoma. World J Gastrointest Surg 2022; 14(9): 1008-1025
URL https://www.wjgnet.com/1948-9366/full/v14/i9/1008.htm
DOI https://dx.doi.org/10.4240/wjgs.v14.i9.1008
Full Article (PDF) WJGS-14-1008.pdf
Full Article (Word) WJGS-14-1008.docx
Manuscript File 75201_Auto_Edited-JJW-WangTQ-LS.docx
Answering Reviewers 75201-Answering reviewers.pdf
Audio Core Tip 75201-Audio core tip.m4a
Biostatistics Review Certificate 75201-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 75201-Conflict-of-interest statement.pdf
Copyright License Agreement 75201-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 75201-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 75201-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 75201-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 75201-Language certificate.pdf
Peer-review Report 75201-Peer-review(s).pdf
Scientific Misconduct Check 75201-Bing-Wang JJ-2.png
Scientific Editor Work List 75201-Scientific editor work list.pdf