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8/3/2022 7:54:39 AM | Browse: 13 | Download: 30
Publication Name World Journal of Gastroenterology
Manuscript ID 75445
Country/Territory Germany
2022-01-28 11:16
Peer-Review Started
2022-01-28 11:18
To Make the First Decision
Return for Revision
2022-04-10 20:32
2022-05-20 08:36
Second Decision
2022-07-11 02:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-11 16:06
Articles in Press
2022-07-11 16:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-07-03 21:38
Typeset the Manuscript
2022-07-25 02:52
Publish the Manuscript Online
2022-08-03 07:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Control Study
Article Title Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List Juliane Malik, Martin Klammer, Vinzent Rolny, Henry Lik-Yuen Chan, Teerha Piratvisuth, Tawesak Tanwandee, Satawat Thongsawat, Wattana Sukeepaisarnjaroen, Juan Ignacio Esteban, Marta Bes, Bruno Köhler and Magdalena Swiatek-de Lange
Author(s) ORCID Number
Juliane Malik http://orcid.org/0000-0003-2306-3920
Martin Klammer http://orcid.org/0000-0001-6426-0029
Vinzent Rolny http://orcid.org/0000-0001-8229-0002
Henry Lik-Yuen Chan http://orcid.org/0000-0002-7790-1611
Teerha Piratvisuth http://orcid.org/0000-0002-5249-9208
Tawesak Tanwandee http://orcid.org/0000-0001-7634-0843
Satawat Thongsawat http://orcid.org/0000-0003-3302-3930
Wattana Sukeepaisarnjaroen http://orcid.org/0000-0001-5065-9397
Juan Ignacio Esteban http://orcid.org/0000-0001-5085-917X
Marta Bes http://orcid.org/0000-0001-6103-072X
Bruno Köhler http://orcid.org/0000-0002-7308-0377
Magdalena Swiatek-de Lange http://orcid.org/0000-0003-1406-3232
Funding Agency and Grant Number
Corresponding Author Juliane Malik, PhD, N/A, N/A, Roche Diagnostics GmbH, Nonnenwald 2, Penzberg 82377, Germany. juliane.malik@roche.com
Key Words Carcinoma; Hepatocellular; MicroRNAs; Biomarkers; Alpha-fetoprotein; Protein induced by vitamin K absence-II; Diagnosis
Core Tip Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has a high mortality rate, making early diagnosis essential for better treatment outcomes. Studies have shown microRNAs to be early markers for HCC; we evaluated the potential diagnostic role of microRNAs alone and in combination with known protein biomarkers (alpha-fetoprotein, protein induced by vitamin K absence/antagonist-II) in samples from HCC-affected individuals and controls using real-time quantitative PCR and next-generation sequencing. MiR-21 and miR-423 demonstrated significant differential expression between the HCC and control groups. MicroRNAs alone or as a signature in combination with protein biomarkers did not improve diagnostic performance of the protein biomarkers.
Publish Date 2022-08-03 07:54
Citation Malik J, Klammer M, Rolny V, Chan HLY, Piratvisuth T, Tanwandee T, Thongsawat S, Sukeepaisarnjaroen W, Esteban JI, Bes M, Köhler B, Swiatek-de Lange M. Comprehensive evaluation of microRNA as a biomarker for the diagnosis of hepatocellular carcinoma. World J Gastroenterol 2022; 28(29): 3917-3933
URL https://www.wjgnet.com/1007-9327/full/v28/i29/3917.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i29.3917
Full Article (PDF) WJG-28-3917.pdf
Full Article (Word) WJG-28-3917.docx
Manuscript File 75445_Auto_Edited-LM.docx
Answering Reviewers 75445-Answering reviewers.pdf
Audio Core Tip 75445-Audio core tip.wav
Biostatistics Review Certificate 75445-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 75445-Conflict-of-interest statement.pdf
Copyright License Agreement 75445-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 75445-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 75445-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 75445-Language certificate.pdf
Supplementary Material 75445-Supplementary material.pdf
Peer-review Report 75445-Peer-review(s).pdf
Scientific Misconduct Check 75445-Bing-Chang KL-2.png
Scientific Editor Work List 75445-Scientific editor work list.pdf