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5/12/2022 8:42:29 AM | Browse: 11 | Download: 22
Publication Name World Journal of Gastroenterology
Manuscript ID 75465
Country/Territory China
Received
2022-01-30 09:13
Peer-Review Started
2022-01-30 09:14
To Make the First Decision
Return for Revision
2022-02-24 05:46
Revised
2022-02-28 08:05
Second Decision
2022-03-18 06:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-03-27 05:22
Articles in Press
2022-03-27 05:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-04-23 07:02
Publish the Manuscript Online
2022-05-12 08:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Microbiology
Manuscript Type Basic Study
Article Title Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model
Manuscript Source Unsolicited Manuscript
All Author List Na Wu, Yu-Qing Feng, Na Lyu, Di Wang, Wei-Dong Yu and Yong-Fei Hu
ORCID
Author(s) ORCID Number
Na Wu http://orcid.org/0000-0001-6803-8337
Yu-Qing Feng http://orcid.org/0000-0002-7742-5272
Na Lyu http://orcid.org/0000-0003-0603-6170
Di Wang http://orcid.org/0000-0003-0553-7977
Wei-Dong Yu http://orcid.org/0000-0002-7573-4979
Yong-Fei Hu http://orcid.org/0000-0002-2158-6018
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 32070116
Open Project Program of CAS Key Laboratory of Pathogenic Microbiology and Immunology CASPMI202102
Corresponding Author Yong-Fei Hu, PhD, Professor, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China. huyongfei@cau.edu.cn
Key Words Fusobacterium nucleatum; Mucosal microbiota; Transcriptome; Colorectal cancer; Inflammation-inducing bacteria
Core Tip Fusobacterium nucleatum (F. nucleatum) has long been known to cause opportunistic infections and has recently been implicated in colorectal cancer (CRC). However, the mechanism by which it is involved in CRC development is not fully understood. Here, striking differences in mucosal microbial population patterns were observed and inflammation-inducing bacteria were enriched in the mucosal microbiota in the azoxymethane/dextran sulfate sodium salt-FUSO group. We showed that transcriptional activity was strongly affected by dysbiosis of the gut microbiota. Additionally, we showed that microbial dysbiosis driven by F. nucleatum infection enriched eight taxa belonging to Proteobacteria, which correlates with increased expression of oncogenic genes.
Publish Date 2022-05-12 08:42
Citation Wu N, Feng YQ, Lyu N, Wang D, Yu WD, Hu YF. Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model. World J Gastroenterol 2022; 28(18): 1981-1995
URL https://www.wjgnet.com/1007-9327/full/v28/i18/1981.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i18.1981
Full Article (PDF) WJG-28-1981.pdf
Full Article (Word) WJG-28-1981.docx
Manuscript File 75465_Auto_Edited.docx
Answering Reviewers 75465-Answering reviewers.pdf
Audio Core Tip 75465-Audio core tip.mp3
Biostatistics Review Certificate 75465-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 75465-Conflict-of-interest statement.pdf
Copyright License Agreement 75465-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 75465-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 75465-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 75465-Language certificate.pdf
Supplementary Material 75465-Supplementary material.pdf
Peer-review Report 75465-Peer-review(s).pdf
Scientific Misconduct Check 75465-Bing-Fan JR-2.png
Scientific Editor Work List 75465-Scientific editor work list.pdf