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6/22/2022 8:29:42 AM | Browse: 21 | Download: 53
Publication Name World Journal of Clinical Oncology
Manuscript ID 75499
Country/Territory Greece
Received
2022-01-31 19:35
Peer-Review Started
2022-01-31 19:36
To Make the First Decision
Return for Revision
2022-04-13 02:00
Revised
2022-04-27 12:44
Second Decision
2022-05-24 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-28 07:17
Articles in Press
2022-05-28 07:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-06-01 06:05
Publish the Manuscript Online
2022-06-22 08:29
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances
Manuscript Source Invited Manuscript
All Author List Kathrine S Rallis, Dimitrios Makrakis, Ioannis A Ziogas and Georgios Tsoulfas
ORCID
Author(s) ORCID Number
Kathrine S Rallis http://orcid.org/0000-0003-1011-3220
Dimitrios Makrakis http://orcid.org/0000-0003-3258-2984
Ioannis A Ziogas http://orcid.org/0000-0002-6742-6909
Georgios Tsoulfas http://orcid.org/0000-0001-5043-7962
Funding Agency and Grant Number
Corresponding Author Georgios Tsoulfas, FACS, FICS, MD, PhD, Professor, Department of Transplantation Surgery, Aristotle University School of Medicine, 66 Tsimiski Street, Thessaloniki 54622, Greece. tsoulfasg@gmail.com
Key Words Hepatocellular carcinoma; Liver cancer; Immunotherapy; Immune checkpoint inhibitors; Clinical trials; Real-world data
Core Tip In the last five years, immune checkpoint inhibitors (ICIs) have entered the treatment landscape of hepatocellular carcinoma (HCC) in the 1st and 2nd line setting. However, due to restrictions in clinical trial inclusion and exclusion criteria, there remains a need for further real-world data on the efficacy, toxicity, and cost-effectiveness of ICIs in a broader cohort of HCC patients. New trials are underway investigating further ICI regimens, including combination therapy strategies, while novel immunotherapies are also being brought to the fore. This review discusses key clinical trials, real-world data, and future advances of immunotherapy for HCC, with a focus on ICIs.
Publish Date 2022-06-22 08:29
Citation Rallis KS, Makrakis D, Ziogas IA, Tsoulfas G. Immunotherapy for advanced hepatocellular carcinoma: From clinical trials to real-world data and future advances. World J Clin Oncol 2022; 13(6): 448-472
URL https://www.wjgnet.com/2218-4333/full/v13/i6/448.htm
DOI https://dx.doi.org/10.5306/wjco.v13.i6.448
Full Article (PDF) WJCO-13-448.pdf
Full Article (Word) WJCO-13-448.docx
Manuscript File 75499_Auto_Edited-LJH-LS.docx
Answering Reviewers 75499-Answering reviewers.pdf
Audio Core Tip 75499-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 75499-Conflict-of-interest statement.pdf
Copyright License Agreement 75499-Copyright license agreement.pdf
Peer-review Report 75499-Peer-review(s).pdf
Scientific Misconduct Check 75499-Bing-Liu JH-2.jpg
Scientific Misconduct Check 75499-CrossCheck.jpg
Scientific Editor Work List 75499-Scientific editor work list.pdf