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8/3/2022 7:54:39 AM | Browse: 20 | Download: 34
Publication Name World Journal of Gastroenterology
Manuscript ID 76404
Country/Territory France
2022-03-15 09:39
Peer-Review Started
2022-03-15 09:42
To Make the First Decision
Return for Revision
2022-05-29 07:16
2022-06-09 05:09
Second Decision
2022-07-01 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-06 03:01
Articles in Press
2022-07-06 03:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-07-25 04:59
Publish the Manuscript Online
2022-08-03 07:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation
Manuscript Source Unsolicited Manuscript
All Author List Geoffroy Mallaret, Amandine Lashermes, Mathieu Meleine, Ludivine Boudieu, Julie Barbier, Youssef Aissouni, Agathe Gelot, Benoit Chassaing, Andrew T Gewirtz, Denis Ardid and Frederic Antonio Carvalho
Author(s) ORCID Number
Geoffroy Mallaret http://orcid.org/0000-0002-3658-3418
Amandine Lashermes http://orcid.org/0000-0002-8241-464X
Mathieu Meleine http://orcid.org/0000-0002-0925-087X
Ludivine Boudieu http://orcid.org/0000-0002-4774-9313
Julie Barbier http://orcid.org/0000-0001-7177-3236
Youssef Aissouni http://orcid.org/0000-0002-9264-7690
Agathe Gelot http://orcid.org/0000-0002-7884-6968
Benoit Chassaing http://orcid.org/0000-0002-4285-769X
Andrew T Gewirtz http://orcid.org/0000-0002-6338-7578
Denis Ardid http://orcid.org/0000-0003-4320-7338
Frederic Antonio Carvalho http://orcid.org/0000-0003-1592-2369
Funding Agency and Grant Number
Funding Agency Grant Number
Region Auvergne-Rhône-Alpes and FEDER Thématiques émergentes
Region Auvergne-Rhône-Alpes and FEDER Pack Ambition Recherche
French Government IDEX-ISITE Initiative 16-IDEX-0001-CAP 20-25
Ministère de la Recherche et de la Technologie, INSERM and University of Clermont Auvergne UMR1071
Corresponding Author Frederic Antonio Carvalho, PhD, Academic Research, Department of Pharmacology, INSERM 1107 NeuroDOL/University of Clermont Auvergne, 28 Place Henri Dunant, Clermont-Ferrand 63000, France. frederic.carvalho@inserm.fr
Key Words Chronic abdominal pain; Colonic hypersensitivity; Toll-like receptors; Intestinal microbiota; Early life events
Core Tip Neonatal maternal separation (NMS) model mimic deleterious events in childhood, which can induce a wide range of chronic disorders during adulthood. Herein, around 50% of NMS mice exhibited increased intestinal permeability and colonic hypersensitivity (CHS) associated with intestinal dysbiosis. Only toll-like receptor 5 (TLR5) mRNA expression was increased in colonocytes of NMS mice with CHS and acute intrarectal instillation of flagellin transiently increased intracolonic pressure variations, reflecting transient CHS appearance. Together, those findings suggest a pathophysiological continuum between intestinal permeability, intestinal dysbiosis and CHS, with a previously undescribed role for TLR5 in CHS.
Publish Date 2022-08-03 07:54
Citation Mallaret G, Lashermes A, Meleine M, Boudieu L, Barbier J, Aissouni Y, Gelot A, Chassaing B, Gewirtz AT, Ardid D, Carvalho FA. Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation. World J Gastroenterol 2022; 28(29): 3903-3916
URL https://www.wjgnet.com/1007-9327/full/v28/i29/3903.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i29.3903
Full Article (PDF) WJG-28-3903.pdf
Full Article (Word) WJG-28-3903.docx
Manuscript File 76404_Auto_Edited-LS.docx
Answering Reviewers 76404-Answering reviewers.pdf
Audio Core Tip 76404-Audio core tip.m4a
Biostatistics Review Certificate 76404-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 76404-Conflict-of-interest statement.pdf
Copyright License Agreement 76404-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 76404-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 76404-Institutional animal care and use committee statement.pdf
Supplementary Material 76404-Supplementary material.pdf
Peer-review Report 76404-Peer-review(s).pdf
Scientific Editor Work List 76404-Scientific editor work list.pdf