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8/31/2022 11:27:51 AM | Browse: 259 | Download: 722
Publication Name World Journal of Gastroenterology
Manuscript ID 77346
Country/Territory Slovakia
Received
2022-05-12 10:49
Peer-Review Started
2022-05-12 10:53
To Make the First Decision
Return for Revision
2022-06-19 04:54
Revised
2022-07-06 18:36
Second Decision
2022-08-11 02:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-16 17:49
Articles in Press
2022-08-16 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-08-25 01:23
Publish the Manuscript Online
2022-08-31 11:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry & Molecular Biology
Manuscript Type Review
Article Title Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Jana Maslankova, Ivana Vecurkovska, Miroslava Rabajdova, Jana Katuchova, Milos Kicka, Michala Gayova and Vladimir Katuch
ORCID
Author(s) ORCID Number
Jana Maslankova http://orcid.org/0000-0002-2786-0620
Miroslava Rabajdova http://orcid.org/0000-0001-9562-5756
Jana Katuchova http://orcid.org/0000-0001-5479-6444
Vladimir Katuch http://orcid.org/0000-0001-8044-4012
Funding Agency and Grant Number
Corresponding Author Jana Katuchova, MD, PhD, Doctor, Professor, Surgeon, First Department of Surgery, Medical Faculty of Safarik University, 1 Trieda SNP, Kosice 04011, Kosicky kraj, Slovakia. jana.katuchova@upjs.sk
Key Words Small mothers against decapentaplegic homologs; Transforming growth factor-beta; Colorectal cancer; Marker; Signaling pathway
Core Tip A thorough understanding of the complete transforming growth factor (TGF)-β/small mothers against decapentaplegic homolog (SMAD) signaling pathway is important for defining its functions during pathological processes of colorectal cancer (CRC). Inhibitors specifically targeting TGF-β pathway mediators that reduce the expression of a particular protein may lead to fewer/milder adverse effects. However, the dual role of the TGF-β pathway in the onset and progression of cancer complicates the physiological/pathological and, thus, clinical situation. In recent years, research has shown that modification of members of this pathway is a promising approach for clinical procedures. Long-term treatment should emphasize personalized and targeted therapy.
Publish Date 2022-08-31 11:27
Citation Maslankova J, Vecurkovska I, Rabajdova M, Katuchova J, Kicka M, Gayova M, Katuch V. Regulation of transforming growth factor-β signaling as a therapeutic approach to treating colorectal cancer. World J Gastroenterol 2022; 28(33): 4744-4761
URL https://www.wjgnet.com/1007-9327/full/v28/i33/4744.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i33.4744
Full Article (PDF) WJG-28-4744.pdf
Full Article (Word) WJG-28-4744.docx
Manuscript File 77346_Auto_Edited-LM.docx
Answering Reviewers 77346-Answering reviewers.pdf
Audio Core Tip 77346-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 77346-Conflict-of-interest statement.pdf
Copyright License Agreement 77346-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 77346-Language certificate.pdf
Peer-review Report 77346-Peer-review(s).pdf
Scientific Misconduct Check 77346-Bing-Chen YL-2.png
Scientific Editor Work List 77346-Scientific editor work list.pdf