| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Pregnancy and fetal outcomes of chronic hepatitis C mothers with viremia in China
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Calvin Q Pan, Bao-Shen Zhu, Jian-Ping Xu, Jian-Xia Li, Li-Juan Sun, Hong-Xia Tian, Xi-Hong Zhang, Su-Wen Li and Er-Hei Dai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Ministry of Science and Technology of China for the National Five-Year Key Projects in Infectious Diseases |
2015ZX10004801 |
|
| Corresponding Author |
Er-Hei Dai, MD, Professor, Division of Liver Disease, Department of Medicine, The Fifth Hospital of Shijiazhuang, Hebei Medical University, No. 42 Ta’nan Road, Yuhua Distinct, Shijiazhuang 050021, Hebei Province, China. daieh2008@126.com |
| Key Words |
Hepatitis C virus viremia; Mother-to-child transmission; Pregnancy complications; Maternal health; Infant hepatitis C virus infection |
| Core Tip |
Although hepatitis C virus (HCV) affects a significant number of pregnant women, there is limited data regarding the impact of HCV active infection on pregnancy and infant outcomes. The current cohort study compared maternal complications and fetal development of HCV mothers with detectable levels of HCV RNA with those of healthy mothers. The study demonstrates a previously unreported association between maternal HCV viremia and a smaller neonate head circumference. In addition, HCV viremia was an independent predictor for negative maternal outcomes including anemia during pregnancy, medical conditions that required caesarian section, and nuchal cords. These findings increase the need for close antenatal surveillance in HCV mothers with viremia for maternal complications and delayed fetal development. |
| Publish Date |
2022-09-07 08:29 |
| Citation |
Pan CQ, Zhu BS, Xu JP, Li JX, Sun LJ, Tian HX, Zhang XH, Li SW, Dai EH. Pregnancy and fetal outcomes of chronic hepatitis C mothers with viremia in China. World J Gastroenterol 2022; 28(34): 5023-5035 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i34/5023.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i34.5023 |
