Publication Name	World Journal of Diabetes
Manuscript ID	7773
Country	Czech Republic

Received	2013-11-30 14:09
Peer-Review Started	2013-12-01 08:46
To Make the First Decision	2014-01-16 08:28
Return for Revision	2014-01-20 22:28
Revised	2014-04-14 21:53
Second Decision	2014-05-16 17:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-16 17:56
Articles in Press	2014-05-23 09:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-06-13 21:02
Publish the Manuscript Online	2014-06-16 15:44

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Topic Highlights
Article Title	Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose gluco- and lipotoxicity by rational supplementation?
Manuscript Source	Invited Manuscript
All Author List	Lukáš Pácal, Katarína Kuricová and Kateřina Kaňková
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Health of Czech Republic NT13198
Corresponding Author	Kate?ina Kaňková, MD, PhD, Department of Pathophysiology, Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic. kankov@med.muni.cz
Key Words	Diabetes; Thiamine; Vitamin B1; Transketolase; Benfotiamine; Hyperglycemia; Nephropathy; Metabolic syndrome; Cardiovascular disease; Chronic kidney disease
Core Tip	Published data suggest deficient action of thiamine in diabetes, however, it is not currently clear by which mechanisms. Plasma levels might be decreased in diabetics (although renal function has a prevailing effect), nevertheless, intracellular concentration of thiamine diphosphate is the crucial parameter and there is not a direct relationship with the plasma thiamine since the rate of transmembrane transport (via thiamine transporters) and intracellular activation by thiamine pyrophosphokinase might affected by hyperglycemia at first place. Experimental studies on the molecular mechanisms of thiamine deficiency in diabetes are critically needed before clear answer to diabetes community could be given.
Publish Date	2014-06-16 15:44
Citation	Pácal L, Kuricová K, Kaňková K. Evidence for altered thiamine metabolism in diabetes: Is there a potential to oppose glucoand lipotoxicity by rational supplementation? World J Diabetes 2014; 5(3): 288-295
URL	http://www.wjgnet.com/1948-9358/full/v5/i3/288.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i3.288

Full Article (PDF)	WJD-5-288.pdf
Full Article (Word)	WJD-5-288.doc
Manuscript File	7773-Review.docx
Answering Reviewers	7773-Answering reviewers.pdf
Copyright License Agreement	7773-Copyright assignment.pdf
Peer-review Report	7773-Peer review(s).pdf
Scientific Editor Work List	7773-Scientific editor work list.pdf