Publication Name	World Journal of Gastroenterology
Manuscript ID	78408
Country	United States

Received	2022-06-24 17:30
Peer-Review Started	2022-06-24 17:33
To Make the First Decision
Return for Revision	2022-08-06 06:52
Revised	2022-08-16 20:42
Second Decision	2022-09-05 03:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-09-06 17:14
Articles in Press	2022-09-06 17:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-09-15 08:44
Publish the Manuscript Online	2022-09-23 10:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Jeffrey Barr Warner, Steven Corrigan Guenthner, Josiah Everett Hardesty, Craig James McClain, Dennis Ray Warner and Irina Andreyevna Kirpich
ORCID	Author(s) ORCID Number Jeffrey Barr Warner http://orcid.org/0000-0003-2022-7854 Steven Corrigan Guenthner http://orcid.org/0000-0003-3561-9607 Josiah Everett Hardesty http://orcid.org/0000-0003-1955-3046 Craig James McClain http://orcid.org/0000-0002-7219-8939 Dennis Ray Warner http://orcid.org/0000-0002-5303-6870 Irina Andreyevna Kirpich http://orcid.org/0000-0002-9545-6451
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health R01AA028905-01A1 National Institutes of Health U01AA026934 National Institutes of Health 1F31AA028423-01A1 National Institutes of Health F32AA027950-01A1 National Institute of General Medical Sciences of the National Institutes of Health P20GM113226 National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health P50AA024337
Corresponding Author	Irina Andreyevna Kirpich, N/A, PhD, Associate Professor, Department of Microbiology and Immunology, University of Louisville School of Medicine, 505 S. Hancock St., Louisville, KY 40202, United States. irina.kirpich@louisville.edu
Key Words	Liver targeted delivery; Nanoparticles; Liposomes; Polymeric nanoparticles; Precision medicine; Alcohol associated liver disease
Core Tip	Alcohol-associated liver disease (ALD) is a common chronic liver disease and global healthcare burden. While a great deal of pre-clinical research attention is paid to ALD, many experimental therapeutics which are administered systemically suffer from poor pharmacokinetics or poor efficacy. Liver-targeted delivery may address these drawbacks while avoiding extra-hepatic side effects. This article reviews literature applying liver-targeted drug delivery platforms such as liposomes, exosomes, polymeric nanoparticles, viruses, and bioengineered bacteria to the treatment of ALD.
Publish Date	2022-09-23 10:13
Citation	Warner JB, Guenthner SC, Hardesty JE, McClain CJ, Warner DR, Kirpich IA. Liver-specific drug delivery platforms: Applications for the treatment of alcohol-associated liver disease. World J Gastroenterol 2022; 28(36): 5280-5299
URL	https://www.wjgnet.com/1007-9327/full/v28/i36/5280.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i36.5280

Full Article (PDF)	WJG-28-5280.pdf
Full Article (Word)	WJG-28-5280.docx
Manuscript File	78408_Auto_Edited-LM.docx
Answering Reviewers	78408-Answering reviewers.pdf
Audio Core Tip	78408-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	78408-Conflict-of-interest statement.pdf
Copyright License Agreement	78408-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	78408-Grant application form(s).pdf
Peer-review Report	78408-Peer-review(s).pdf
Scientific Misconduct Check	78408-Bing-Gao CC-2.png
Scientific Editor Work List	78408-Scientific editor work list.pdf