Publication Name	World Journal of Orthopedics
Manuscript ID	79055
Country	United States

Received	2022-07-30 19:14
Peer-Review Started	2022-07-30 19:17
To Make the First Decision
Return for Revision	2022-10-24 02:54
Revised	2022-11-22 02:43
Second Decision	2023-02-13 04:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-02-13 07:40
Articles in Press	2023-02-13 07:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-02-17 05:56
Publish the Manuscript Online	2023-03-17 13:03

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Review
Article Title	Utility of D-dimer in total joint arthroplasty
Manuscript Source	Unsolicited Manuscript
All Author List	Brenden Cutter, Zachary C Lum, Mauro Giordani and John P Meehan
ORCID	Author(s) ORCID Number Brenden Cutter http://orcid.org/0000-0003-4478-230X Zachary C Lum http://orcid.org/0000-0002-5871-8539 Mauro Giordani http://orcid.org/0000-0002-7518-3361
Funding Agency and Grant Number
Corresponding Author	Brenden Cutter, Consultant, Doctor, Doctor, Department of Orthopedic Surgery, Valley Orthopedic Surgery Residency/Valley Consortium for Medical Education, 1400 Florida Ave #102, Modesto, CA 95351, United States. bcutter16@gmail.com
Key Words	D-dimer; Diagnosis; Periprosthetic joint infection; Venous thromboembolism; Deep vein thrombosis; Arthroplasty
Core Tip	Venous thromboembolism (VTE) and periprosthetic joint infection (PJI) are potentially devastating complications after total joint arthroplasty. D-dimer has limited utility with current cutoff values in the detection of VTE in the acute postoperative period. The D-dimer assay is a valuable biomarker in the diagnosis of chronic periprosthetic joint infection, and its utility may be optimized by using serum sample technique. Larger prospective trials with transparent lab testing protocols are necessary to establish best assay practices and optimal cutoff values for D-dimer in the diagnosis of VTE and PJI in arthroplasty patients.
Publish Date	2023-03-17 13:03
Citation	Cutter B, Lum ZC, Giordani M, Meehan JP. Utility of D-dimer in Total Joint Arthroplasty. World J Orthop 2023; 14(3): 90-102
URL	https://www.wjgnet.com/2218-5836/full/v14/i3/90.htm
DOI	https://dx.doi.org/10.5312/wjo.v14.i3.90

Full Article (PDF)	WJO-14-90.pdf
Full Article (Word)	WJO-14-90.docx
Manuscript File	79055_Auto_Edited-LJH-JLW.docx
Answering Reviewers	79055-Answering reviewers.pdf
Audio Core Tip	79055-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	79055-Conflict-of-interest statement.pdf
Copyright License Agreement	79055-Copyright license agreement.pdf
Peer-review Report	79055-Peer-review(s).pdf
Scientific Misconduct Check	79055-Bing-Liu JH-2.jpg
Scientific Misconduct Check	79055-CrossCheck.jpg
Scientific Editor Work List	79055-Scientific editor work list.pdf
CrossCheck Report	79055-CrossCheck report.pdf