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Publication Name World Journal of Gastroenterology
Manuscript ID 79222
Country Thailand
2022-08-13 23:23
Peer-Review Started
2022-08-10 02:28
To Make the First Decision
Return for Revision
2022-10-20 20:28
2022-10-25 03:39
Second Decision
2022-11-18 04:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-11-19 00:50
Articles in Press
2022-11-19 00:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-12-15 00:55
Typeset the Manuscript
2022-12-30 04:16
Publish the Manuscript Online
2023-01-06 02:52
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Minireviews
Article Title Current opinion in the regulation of small intestinal magnesium absorption
Manuscript Source Invited Manuscript
All Author List Siriporn Chamniansawat, Nasisorn Suksridechacin and Narongrit Thongon
Author(s) ORCID Number
Siriporn Chamniansawat http://orcid.org/0000-0003-2609-6373
Nasisorn Suksridechacin http://orcid.org/0000-0002-0236-6650
Narongrit Thongon http://orcid.org/0000-0003-2475-9161
Funding Agency and Grant Number
Corresponding Author Narongrit Thongon, PhD, Associate Professor, Division of Physiology, Department of Medical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Road, Saensook, Muang 20131, Chonburi, Thailand. narongritt@buu.ac.th
Key Words Hormone; Mg2+ absorption; Paneth cells; Proton pump inhibitor; Regulation; Small intestine
Core Tip Small-intestinal epithelium absorbs digested Mg2+ through both transcellular active and paracellular passive mechanisms. Several regulatory factors of small-intestinal Mg2+ uptake have been reported. Parathyroid hormone and fibroblast growth factor-23 directly inhibit transcellular Mg2+ absorption in the duodenum, jejunum, and ileum. The apical proton triggered acid-sensing ion-channel 1a and purinergic P2Y2 receptor activities, which stimulated mucosal bicarbonate secretion (MBS). Secreted bicarbonate induced MgCO3 precipitation that suppressed small-intestinal Mg2+ absorption. Omeprazole suppressed Mg2+ absorption in the duodenum, jejunum, and ileum via higher MBS, lower mucosal transient receptor potential melastatin 6 homodimer channel and transient receptor potential melastatin 6/7 homodimer channel activity, Paneth cell dysfunction, and higher intestinal inflammation and villous atrophy.
Publish Date 2023-01-06 02:52
Citation Chamniansawat S, Suksridechacin N, Thongon N. Current opinion in the regulation of small intestinal magnesium absorption. World J Gastroenterol 2023; 29(2): 332-342
URL https://www.wjgnet.com/1007-9327/full/v29/i2/332.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i2.332
Full Article (PDF) WJG-29-332.pdf
Full Article (Word) WJG-29-332.docx
Manuscript File 79222-Review-FilipodiaCL.docx
Answering Reviewers 79222-Answering reviewers.pdf
Audio Core Tip 79222-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 79222-Conflict-of-interest statement.pdf
Copyright License Agreement 79222-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 79222-Language certificate.pdf
Peer-review Report 79222-Peer-review(s).pdf
Scientific Misconduct Check 79222-Bing-Fan JR-2.png
Scientific Editor Work List 79222-Scientific editor work list.pdf
CrossCheck Report 79222-CrossCheck report.pdf
CrossCheck Report 79222-CrossCheck.png