Publication Name	World Journal of Gastroenterology
Manuscript ID	79802
Country	China

Received	2022-09-07 07:27
Peer-Review Started	2022-09-07 07:30
To Make the First Decision
Return for Revision	2022-10-19 21:59
Revised	2022-11-01 05:16
Second Decision	2022-12-05 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-12-05 17:42
Articles in Press	2022-12-05 17:42
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-12-02 00:56
Typeset the Manuscript	2022-12-26 08:08
Publish the Manuscript Online	2023-01-04 05:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Basic Study
Article Title	In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Ping Yu, Yan-Juan Li, Tao Wang, Yu-Xuan Tao, Mei Zhang, Wen Gu, Jie Yu and Xing-Xin Yang
ORCID	Author(s) ORCID Number Li-Ping Yu http://orcid.org/0000-0003-3914-0003 Yan-Juan Li http://orcid.org/0000-0003-3377-8014 Tao Wang http://orcid.org/0000-0002-8863-0853 Jie Yu http://orcid.org/0000-0001-8100-8896 Xing-Xin Yang http://orcid.org/0000-0001-6594-772X
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82060707, 82104381 Application and Basis Research Project of Yunnan China 202201AW070016, 202001AZ070001-006, 2019IB009 Young and Middle-aged Academic and Technological Leader of Yunnan 202005AC160059
Corresponding Author	Xing-Xin Yang, PharmD, Associate Professor, College of Pharmaceutical Science, Yunnan University of Chinese Medicine, No. 1076 Yuhua Road, Kunming 650500, Yunnan Province, China. yxx78945@163.com
Key Words	Fatty liver; Mitochondria; Pharmacodynamic ingredients; Polygonum multiflorum
Core Tip	We found that Polygonum multiflorum (PM) protected the mitochondrial ultrastructure and prevented oxidative stress and energy production disorder in the liver mitochondria to mitigate metabolic dysfunction-associated fatty liver disease (MAFLD). Eight chemicals were identified from the liver mitochondria of the PM-treated rats using a novel strategy based on mitochondrial pharmacology and pharmacochemistry. The constituents identified regulated mitochondria to alleviate MAFLD. Our results indicate that PM restored mitochondrial structure and function and alleviated MAFLD, which may be related to oxidative stress and energy production. The eight substances may be the main pharmacodynamic ingredients in PM that regulate mitochondria to prevent MAFLD.
Publish Date	2023-01-04 05:53
Citation	Yu LP, Li YJ, Wang T, Tao YX, Zhang M, Gu W, Yu J, Yang XX. In vivo recognition of bioactive substances of Polygonum multiflorum for protecting mitochondria against metabolic dysfunction-associated fatty liver disease. World J Gastroenterol 2023; 29(1): 171-189
URL	https://www.wjgnet.com/1007-9327/full/v29/i1/171.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i1.171

Full Article (PDF)	WJG-29-171.pdf
Full Article (Word)	WJG-29-171.docx
Manuscript File	79802_Auto_Edited-LM.docx
Answering Reviewers	79802-Answering reviewers.pdf
Audio Core Tip	79802-Audio core tip.mp3
Biostatistics Review Certificate	79802-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	79802-Conflict-of-interest statement.pdf
Copyright License Agreement	79802-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	79802-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	79802-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	79802-Language certificate.pdf
Peer-review Report	79802-Peer-review(s).pdf
Scientific Misconduct Check	79802-Bing-Wang JJ-2.png
Scientific Editor Work List	79802-Scientific editor work list.pdf