Publication Name	World Journal of Stem Cells
Manuscript ID	82012
Country	Argentina

Received	2022-12-26 14:10
Peer-Review Started	2022-12-26 14:12
To Make the First Decision
Return for Revision	2023-02-16 23:46
Revised	2023-03-06 19:08
Second Decision	2023-04-03 03:44
Accepted by Journal Editor-in-Chief	2023-04-04 14:43
Accepted by Executive Editor-in-Chief	2023-04-17 08:34
Articles in Press	2023-04-17 08:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-05-17 08:36
Publish the Manuscript Online	2023-05-26 11:17

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells
Manuscript Source	Invited Manuscript
All Author List	María Belén Novoa Díaz, Pedro Carriere and Claudia Gentili
ORCID	Author(s) ORCID Number María Belén Novoa Díaz http://orcid.org/0000-0002-6684-4076 Pedro Carriere http://orcid.org/0000-0002-5751-8850 Claudia Gentili http://orcid.org/0000-0002-9957-7824
Funding Agency and Grant Number	Funding Agency Grant Number Agencia Nacional de Promoción Científica y Tecnológica PICT-2020-SERIEA-03440 and PICT-2013-1441 Consejo Nacional de Investigaciones Científicas y Técnicas PIP11220200103061CO and PIP11220150100350CO Instituto Nacional del Cáncer Asistencia Financiera II, RESOL 493/14 2002-4395-14-1 Instituto Nacional del Cáncer Asistencia Financiera III-2016-2017, RESOL-2016-1006-E-APN-MS 2002-3862-16-1 CANCER Universidad Nacional del Sur PGI: 24/B230 and PGI: 24/B303 Fundación Alberto J Roemmers of Argentina
Corresponding Author	Claudia Gentili, PhD, Professor, Research Scientist, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, 670 San Juan, Bahía Blanca 8000, Buenos Aires, Argentina. cgentili@criba.edu.ar
Key Words	Colorectal cancer; Colorectal cancer stem cells; Tumor microenvironment factors; Tumor stroma; Gut microbiota; Cancer progression
Core Tip	Colorectal cancer (CRC) represents one of the most prevalent tumors worldwide. The tumor microenvironment (TME) through its proinflammatory role, among others, actively participates in CRC progression and the disturbance of gut microbiota (dysbiosis) can influence this inflammatory process. CRC stem cells (CCSC) are a tumor cell subpopulation that drives CRC initiation, progression and treatment failure. The features and behavior of CCSC are modulated by several factors including TME and gut microbiota. Here, we will give an overview of the synergistic interaction among TME and intestinal microorganisms that condition the CRC environment and shape CCSC characteristics allowing CRC evolution.
Publish Date	2023-05-26 11:17
Citation	Novoa Díaz MB, Carriere P, Gentili C. How the interplay among the tumor microenvironment and the gut microbiota influence the stemness of colorectal cancer cells. World J Stem Cells 2023; 15(5): 281-301
URL	https://www.wjgnet.com/1948-0210/full/v15/i5/281.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i5.281

Full Article (PDF)	WJSC-15-281.pdf
Full Article (Word)	WJSC-15-281.docx
Manuscript File	82012_Auto_Edited-JLW.docx
Answering Reviewers	82012-Answering reviewers.pdf
Audio Core Tip	82012-Audio core tip.ogg
Conflict-of-Interest Disclosure Form	82012-Conflict-of-interest statement.pdf
Copyright License Agreement	82012-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82012-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	82012-Language certificate.pdf
Peer-review Report	82012-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	82012-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	82012-Bing-Li L-2.png
Scientific Editor Work List	82012-Scientific editor work list.pdf
CrossCheck Report	82012-CrossCheck report.pdf
CrossCheck Report	82012-CrossCheck.png