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5/25/2023 4:10:55 PM | Browse: 88 | Download: 237
Publication Name World Journal of Clinical Cases
Manuscript ID 83901
Country China
Received
2023-02-16 09:03
Peer-Review Started
2023-02-16 09:04
To Make the First Decision
Return for Revision
2023-03-28 07:50
Revised
2023-04-07 12:28
Second Decision
2023-04-19 02:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-04-19 07:31
Articles in Press
2023-04-19 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-05-12 03:50
Publish the Manuscript Online
2023-05-25 16:10
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Hematology
Manuscript Type Case Report
Article Title Co-existing squamous cell carcinoma and chronic myelomonocytic leukemia with ASXL1 and EZH2 gene mutations: A case report
Manuscript Source Unsolicited Manuscript
All Author List Lai-Jun Deng, Yang Dong, Mi-Mi Li and Chang-Gang Sun
ORCID
Author(s) ORCID Number
Lai-Jun Deng http://orcid.org/0000-0002-2513-4991
Funding Agency and Grant Number
Corresponding Author Lai-Jun Deng, MS, Staff Physician, Department of Hematology, Weifang Hospital of Traditional Chinese Medicine, No. 1055 Weizhou Road, Kuiwen District, Weifang 261000, Shandong Province, China. denglaijun1982@163.com
Key Words Squamous cell carcinoma; Chronic myelomonocytic leukemia; Myeloproliferative neoplasms; Myelodysplastic; ASXL1gene mutations; EZH2 gene mutations; Case report
Core Tip A 63-year-old male, with a long history of heavy smoking, was diagnosed with chronic myelomonocytic leukemia (CMML), with additional sex combs-like and enhancer of zeste homolog 2 gene mutations, as well as non-small cell lung cancer (squamous cell carcinoma). However, no such mutations were found in the lung cancer tissue. In CMML patients, pulmonary manifestations are non-specific, and the rare presence of malignant tumors in the lungs poses challenges in diagnosis. After receiving azacitidine, programmed cell death protein 1, and platinum-based chemotherapy drugs, the patient developed severe myelosuppression and eventually fatal leukocyte stasis and dyspnea. Therefore, during treatment and observation of CMML, medical practitioners should pay attention to the occurrence and evolution of solid tumors such as lung cancer, and be vigilant of the growth of multiple primary malignant tumors.
Publish Date 2023-05-25 16:10
Citation Deng LJ, Dong Y, Li MM, Sun CG. Co-existing squamous cell carcinoma and chronic myelomonocytic leukemia with ASXL1 and EZH2 gene mutations: A case report. World J Clin Cases 2023; 11(15): 3643-3650
URL https://www.wjgnet.com/2307-8960/full/v11/i15/3643.htm
DOI https://dx.doi.org/10.12998/wjcc.v11.i15.3643
Full Article (PDF) WJCC-11-3643.pdf
Full Article (Word) WJCC-11-3643.docx
CARE Checklist–2016 83901-CARE-Checklist–2016-revision.pdf
Manuscript File 83901_Auto_Edited-LJH-JLW.docx
Answering Reviewers 83901-Answering reviewers.pdf
Audio Core Tip 83901-Audio core tip.wav
Conflict-of-Interest Disclosure Form 83901-Conflict-of-interest statement.pdf
Copyright License Agreement 83901-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s) 83901-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate 83901-Language certificate.pdf
Peer-review Report 83901-Peer-review(s).pdf
Scientific Misconduct Check 83901-Bing-Liu JH-2.png
Scientific Misconduct Check 83901-CrossCheck.png
Scientific Editor Work List 83901-Scientific editor work list.pdf