| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kuan He, Chao-Zheng Xie, Ya Li, Zhen-Zhou Chen, Shi-Hao Xu, Si-Qi Huang, Jian-Guo Yang, Zheng-Qiang Wei and Xu-Dong Peng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Chongqing Key Diseases Research and Application Demonstration Program |
No. 2019ZX003 |
| General Project of Chongqing Nature Science Foundation |
No. cstc2021jcyj-msxmX0283 |
|
| Corresponding Author |
Xu-Dong Peng, PhD, Doctor, Doctor, Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400000, China. 846393577@qq.com |
| Key Words |
Colorectal cancer; Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000; Proliferation; Migration; Phosphoinositide 3-kinase; Akt |
| Core Tip |
Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 (DARPP-32) is frequently upregulated in colorectal cancer (CRC). Overexpression of DARPP-32 promotes cancer cell proliferation, migration, invasion and reduces apoptosis. Mechanistic investigations reveal that DARPP-32 may exert its oncogenic functions through regulation of the phosphoinositide 3-kinase/AKT signaling pathway which is involved in cell survival and proliferation. These findings indicate that DARPP-32 plays an essential role in facilitating colorectal tumorigenesis and progression. Therefore, DARPP-32 may represent a potential novel biomarker and therapeutic target for CRC treatment. |
| Publish Date |
2023-11-15 13:46 |
| Citation |
He K, Xie CZ, Li Y, Chen ZZ, Xu SH, Huang SQ, Yang JG, Wei ZQ, Peng XD. Dopamine and cyclic adenosine monophosphate-regulated phosphoprotein with an apparent Mr of 32000 promotes colorectal cancer growth. World J Gastrointest Oncol 2023; 15(11): 1936-1950 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i11/1936.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i11.1936 |
