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Articles Published Processes
9/1/2023 8:11:23 AM | Browse: 275 | Download: 803
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Received |
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2023-05-25 14:22 |
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Peer-Review Started |
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2023-05-25 14:25 |
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To Make the First Decision |
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Return for Revision |
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2023-07-08 13:07 |
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Revised |
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2023-07-27 15:34 |
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Second Decision |
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2023-08-11 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2023-08-15 17:19 |
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Articles in Press |
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2023-08-15 17:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-08-28 03:38 |
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Publish the Manuscript Online |
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2023-09-01 08:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ying Wu, Ai-Hong Yin, Jun-Tao Sun, Wei-Hua Xu and Chun-Qing Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Provincial Natural Science Foundation |
ZR2021MH389 |
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| Corresponding Author |
Wei-Hua Xu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, NO. 247 Beiyuan Street, Jinan 250033, Shandong Province, China. xuweihua1967@126.com |
| Key Words |
Angiotensin-converting enzyme 2; Hepatic stellate cells; Autophagy; Liver fibrosis; Portal hypertension; Mice |
| Core Tip |
Liver fibrosis and cirrhosis are the common outcomes of most chronic liver diseases, and there is a lack of effective treatment at present. Angiotensin-converting enzyme 2 (ACE2), as the main target receptor for the coronavirus disease virus invasion into the human body, is one of the research hotspots. The involvement of autophagy in the activation mechanism of hepatic stellate cell (HSC) during liver fibrosis has attracted increasing attention. Our study found that ACE2 can inhibit the activation and proliferation of HSCs by regulating autophagy, and promote apoptosis of HSCs, providing new ideas for the treatment of liver fibrosis and hepatic sinusoidal remodeling. |
| Publish Date |
2023-09-01 08:11 |
| Citation |
Wu Y, Yin AH, Sun JT, Xu WH, Zhang CQ. Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells. World J Gastroenterol 2023; 29(33): 4975-4990 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i33/4975.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i33.4975 |
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