Publication Name	World Journal of Orthopedics
Manuscript ID	8713
Country	Germany

Received	2014-01-03 16:54
Peer-Review Started	2014-01-03 21:20
To Make the First Decision	2014-02-27 10:01
Return for Revision	2014-03-10 20:28
Revised	2014-03-14 19:39
Second Decision	2014-06-11 12:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-11 12:34
Articles in Press	2014-06-11 13:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-11 08:38
Publish the Manuscript Online	2014-08-20 20:37

ISSN	2218-5836 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Topic Highlights
Article Title	Enhanced microfracture techniques in cartilage knee surgery: Fact or fiction?
Manuscript Source	Invited Manuscript
All Author List	Stefan Bark, Tomasz Piontek, Peter Behrens, Sabreen Mkalaluh, Deike Varoga and Justus Gille
Funding Agency and Grant Number
Corresponding Author	Bark Stefan, MD, Department of Trauma and Reconstructive Surgery, University of Schleswig-Holstein, Ratzeburger Allee 160, 23538 Campus Luebeck, Germany. stefan.bark@uksh.de
Key Words	Cartilage; Microfracture; Autologous; Matrix-Induced Chondrogenesis; Knee; Chondro-Gide?
Core Tip	Articular cartilage has a limited healing potential which presents a well-known circumstance in orthopedic surgery. This fact has led to a variety of surgical techniques for treating articular defects and currently the microfracturing presents the most commonly used procedure. The aim of this article is to give an overview about actual studies regarding microfracture and the AMIC? technique in cartilage knee surgery and to show recent developments.This article reviews the pre-clinical rationale of microfractures and AMIC?, presents clinical studies and shows the advantages and disadvantages of these widely used techniques. Material and Methods PubMed and the Cochrane database were searched to identify relevant studies. We used a comprehensive search strategy with no date or language restrictions to locate studies that examined the AMIC? technique and microfracture. Search keywords included cartilage, microfracture, AMIC?, knee, Chondro-Gide?. Besides this, we included our own experiences and study authors were contacted if more and non published data were needed. Results Both cartilage repair techniques represent an effective and safe method of treating full-thickness chondral defects of the knee in selected cases. While results after microfracture deteriorate with time, mid-term results after AMIC? seem to be enduring. Conclusion Randomized studies with long-term follow-up are needed whether the grafted area will maintain functional improvement and structural integrity over time.
Publish Date	2014-08-20 20:37
Citation	Bark S, Piontek T, Peter B, Mkalaluh S, Varoga D, Gille J. Enhanced microfracture techniques in cartilage knee surgery: Fact or fiction? World J Orthop 2014; 5(4): 444-449
URL	http://www.wjgnet.com/2218-5836/full/v5/i4/444.htm
DOI	http://dx.doi.org/10.5312/wjo.v5.i4.444

Full Article (PDF)	WJO-5-444.pdf
Full Article (Word)	WJO-5-444.doc
Manuscript File	8713-Review.docx
Answering Reviewers	8713-Answering reviewers.pdf
Copyright License Agreement	8713-Copyright assignment.pdf
Peer-review Report	8713-Peer review(s).pdf
Scientific Misconduct Check	8713-CorssCheck.jpg
Scientific Editor Work List	8713-Scientific editor work list.pdf