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8/25/2014 2:47:00 PM | Browse: 395 | Download: 416
Publication Name World Journal of Gastroenterology
Manuscript ID 8918
Country of Manuscript Source Japan
Received
2014-01-11 14:54
Peer-Review Started
2014-01-11 16:34
To Make the First Decision
2014-02-14 13:43
Return for Revision
2014-02-20 11:14
Revised
2014-03-01 14:12
Second Decision
2014-04-23 09:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-23 10:21
Articles in Press
2014-05-23 09:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-07-23 20:11
Publish the Manuscript Online
2014-08-07 10:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript type Autobiography
Article Title IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions
Manuscript Source Unsolicited Manuscript
All Author List Takafumi Naito, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Kei Mitsuhashi, Shinji Yoshii, Hironori Aoki, Masafumi Nomura, Yasutaka Sukawa, Eiichiro Yamamoto, Yasushi Adachi, Hiroaki Takahashi, Masao Hosokawa, Masahiro Fujita, Toshinao Takenouchi, Reo Maruyama, Hiromu Suzuki, Yoshifumi Baba, Kohzoh Imai, Hiroyuki Yamamoto, Shuji Ogino and Yasuhisa Shinomura
Funding Agency and Grant Number
Funding Agency Grant Number
Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research 23790800 (to Nosho K)
Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research 23390200 (to Shinomura Y)
A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R and D) to Nosho K
Daiwa Securities Health Foundation to Nosho K
Kobayashi Foundation for Cancer Research to Nosho K
Sagawa Foundation for Promotion of Cancer Research to Nosho K
Suzuken Memorial Foundation to Nosho K
Takeda Science Foundation to Nosho K
USA National Institute of Health R01 CA151993 (to Ogino S)
Correspondence To Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chou-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp
Keywords BRAF; Colon polyp; Colorectal neoplasia; Colorectum; Genome; Insulin-like growth factor; Long interspersed nucleotide element-1; Microsatellite instability; Serrated pathway
Core Tip The serrated pathway attracts considerable attention as an alternative colorectal cancer (CRC) pathway. We previously reported the association of insulin-like growth factor 2 (IGF2) differentially methylated region (DMR)0 hypomethylation with prognosis and its link to LINE-1 hypomethylation in CRC; however, there have been no studies describing its role in the serrated pathway. Therefore, we evaluated the methylation levels of IGF2 DMR0 and long interspersed nucleotide element-1 (LINE-1) in 351 serrated lesions and 185 non-serrated adenomas. Our results suggest that the IGF2 DMR0 may be an infrequent epigenetic alteration in the sessile serrated adenoma pathway. Moreover, we found that the hypomethylation of IGF2 DMR0 and LINE-1 may play an important role in the progression of traditional serrated adenoma.
Publish Date 2014-08-07 10:34
Citation Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y. IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol 2014; 20(29): 10050-10061
Url http://www.wjgnet.com/1007-9327/full/v20/i29/10050.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i29.10050
Full Article (PDF) WJG-20-10050.pdf
Full Article (Word) WJG-20-10050.doc
Manuscript File 8918-Review.docx
Answering Reviewers 8918-Answering reviewers.pdf
Copyright License Agreement 8918-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 8918-Language certificate.pdf
Peer-review Report 8918-Peer reviews.pdf
Scientific Editor Work List 8918-Scientific editor work list.doc