| Category |
Oncology |
| Manuscript Type |
Autobiography |
| Article Title |
IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Takafumi Naito, Katsuhiko Nosho, Miki Ito, Hisayoshi Igarashi, Kei Mitsuhashi, Shinji Yoshii, Hironori Aoki, Masafumi Nomura, Yasutaka Sukawa, Eiichiro Yamamoto, Yasushi Adachi, Hiroaki Takahashi, Masao Hosokawa, Masahiro Fujita, Toshinao Takenouchi, Reo Maruyama, Hiromu Suzuki, Yoshifumi Baba, Kohzoh Imai, Hiroyuki Yamamoto, Shuji Ogino and Yasuhisa Shinomura |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research |
23790800 (to Nosho K) |
| Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research |
23390200 (to Shinomura Y) |
| A-STEP (Adaptable and Seamless Technology Transfer Program through Target-driven R and D) |
to Nosho K |
| Daiwa Securities Health Foundation |
to Nosho K |
| Kobayashi Foundation for Cancer Research |
to Nosho K |
| Sagawa Foundation for Promotion of Cancer Research |
to Nosho K |
| Suzuken Memorial Foundation |
to Nosho K |
| Takeda Science Foundation |
to Nosho K |
| USA National Institute of Health |
R01 CA151993 (to Ogino S) |
|
| Corresponding Author |
Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chou-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp |
| Key Words |
BRAF; Colon polyp; Colorectal neoplasia; Colorectum; Genome; Insulin-like growth factor; Long interspersed nucleotide element-1; Microsatellite instability; Serrated pathway |
| Core Tip |
The serrated pathway attracts considerable attention as an alternative colorectal cancer (CRC) pathway. We previously reported the association of insulin-like growth factor 2 (IGF2) differentially methylated region (DMR)0 hypomethylation with prognosis and its link to LINE-1 hypomethylation in CRC; however, there have been no studies describing its role in the serrated pathway. Therefore, we evaluated the methylation levels of IGF2 DMR0 and long interspersed nucleotide element-1 (LINE-1) in 351 serrated lesions and 185 non-serrated adenomas. Our results suggest that the IGF2 DMR0 may be an infrequent epigenetic alteration in the sessile serrated adenoma pathway. Moreover, we found that the hypomethylation of IGF2 DMR0 and LINE-1 may play an important role in the progression of traditional serrated adenoma. |
| Publish Date |
2014-08-07 10:34 |
| Citation |
Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y. IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. World J Gastroenterol 2014; 20(29): 10050-10061 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i29/10050.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i29.10050 |
