Publication Name	World Journal of Gastroenterology
Manuscript ID	9281
Country

Received	2014-01-29 22:30
Peer-Review Started	2014-02-08 13:32
To Make the First Decision	2014-02-27 13:53
Return for Revision	2014-03-13 19:02
Revised	2014-04-10 05:01
Second Decision	2014-05-14 09:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-14 09:29
Articles in Press	2014-05-23 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-02 18:42
Publish the Manuscript Online	2014-09-19 19:25

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Meta-Analysis
Article Title	Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Mari Nanna Øines, Peter-Martin Krarup, Lars Nannestad Jorgensen and Magnus Sven Ågren
Funding Agency and Grant Number
Corresponding Author	Magnus Sven Ågren, Professor, Digestive Disease Center, Bispebjerg Hospital, University of Copenhagen, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark. magnus.agren@mail.dk
Key Words	Anastomotic healing; Colorectal surgery; Experimental; Breaking strength; Bursting pressure; Collagen; Meta-analysis
Core Tip	Anastomotic leakage after colorectal surgery is an ongoing challenge and results in high morbidity and mortality. Currently, there is no pharmaceutical compound specifically indicated for the improvement of anastomotic healing. This situation is remarkable considering the many interventions that have been assessed under experimental conditions. This study reviewed 56 therapeutic agents investigated in 75 separate studies. Iloprost, tacrolimus, erythropoietin, growth hormone, insulin-like growth factor-1, hyperbaric oxygen and matrix metalloproteinase inhibitor therapies reproducibly improved anastomosis stability in experimental models. These therapies, alone or in combination, should be explored further.
Publish Date	2014-09-19 19:25
Citation	Øines MN, Krarup PM, Jorgensen LN, Ågren MS. Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis. World J Gastroenterol 2014; 20(35): 12637-12648
URL	http://www.wjgnet.com/1007-9327/full/v20/i35/12637.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i35.12637

Full Article (PDF)	WJG-20-12637.pdf
Full Article (Word)	WJG-20-12637.doc
Manuscript File	9281-Review.docx
Answering Reviewers	9281-Answering reviewers.pdf
Copyright License Agreement	9281-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	9281-Language certificate.pdf
Peer-review Report	9281-Peer reviews.pdf
Scientific Editor Work List	9281-Scientific editor work list.pdf