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10/20/2014 6:36:00 PM | Browse: 493 | Download: 407
Publication Name World Journal of Gastroenterology
Manuscript ID 9647
Country of Manuscript Source Japan
Received
2014-02-22 11:53
Peer-Review Started
2014-02-22 13:58
To Make the First Decision
2014-03-27 21:13
Return for Revision
2014-04-04 15:11
Revised
2014-04-17 00:00
Second Decision
2014-05-26 21:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-26 21:52
Articles in Press
2014-05-26 22:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-10-09 11:05
Publish the Manuscript Online
2014-10-20 18:35
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Autobiography
Article Title Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine
Manuscript Source Unsolicited Manuscript
All Author List Shigeo Koido, Toshifumi Ohkusa, Shin Kan, Kazuki Takakura, Keisuke Saito, Hideo Komita, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Kan Uchiyama, Hiroshi Arakawa, Masaki Ito, Masato Okamoto, Mikio Kajihara, Sadamu Homma and Hisao Tajiri
Funding Agency and Grant Number
Funding Agency Grant Number
Grants-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan
Foundation for the Promotion of Cancer Research
Mitsui Life Social Welfare Foundation
Correspondence To Shigeo Koido, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba 277-8564, Japan. shigeo_koido@jikei.ac.jp
Keywords Commensal bacteria; Corticotropin-releasing factor; Dendritic cell; Irritable bowel syndrome; Inflammatory bowel disease; Urocortin
Core Tip Corticotropin-releasing factor (CRF) and urocortin 1 (UCN1) play critical roles in many stress-related intestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. However, little is known about the pathophysiology of these diseases. To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation, human peripheral blood monocyte-derived dendritic cells were stimulated by commensal bacterial strains. Both CRF and UCN1 were significantly augmented by Bacteroides vulgatus (B. vulgatus) and Fusobacterium varium (F. varium) at both the mRNA and protein levels. Thus, B. vulgatus and F. varium may be associated with stress-related intestinal disorders.
Publish Date 2014-10-20 18:35
Citation Koido S, Ohkusa T, Kan S, Takakura K, Saito K, Komita H, Ito Z, Kobayashi H, Takami S, Uchiyama K, Arakawa H, Ito M, Okamoto M, Kajihara M, Homma S, Tajiri H. Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine. World J Gastroenterol 2014; 20(39): 14420-14429
Url http://www.wjgnet.com/1007-9327/full/v20/i39/14420.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i39.14420
Full Article (PDF) WJG-20-14420.pdf
Full Article (Word) WJG-20-14420.doc
Manuscript File 9647-Review.docx
Answering Reviewers 9647-Answering reviewers.pdf
Copyright License Agreement 9647-Copyright Assignment.pdf
Peer-review Report 9647-Peer review.pdf
Scientific Misconduct Check 9647-CrossCheck.jpg
Scientific Editor Work List 9647-Scientific editor work list.pdf