| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Autobiography |
| Article Title |
Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shigeo Koido, Toshifumi Ohkusa, Shin Kan, Kazuki Takakura, Keisuke Saito, Hideo Komita, Zensho Ito, Hiroko Kobayashi, Shinichiro Takami, Kan Uchiyama, Hiroshi Arakawa, Masaki Ito, Masato Okamoto, Mikio Kajihara, Sadamu Homma and Hisao Tajiri |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Grants-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan |
|
| Foundation for the Promotion of Cancer Research |
|
| Mitsui Life Social Welfare Foundation |
|
|
| Corresponding Author |
Shigeo Koido, MD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine, 163-1 Kashiwa-shita, Kashiwa, Chiba 277-8564, Japan. shigeo_koido@jikei.ac.jp |
| Key Words |
Commensal bacteria; Corticotropin-releasing factor; Dendritic cell; Irritable bowel syndrome; Inflammatory bowel disease; Urocortin |
| Core Tip |
Corticotropin-releasing factor (CRF) and urocortin 1 (UCN1) play critical roles in many stress-related intestinal disorders, such as irritable bowel syndrome and inflammatory bowel disease. However, little is known about the pathophysiology of these diseases. To examine whether commensal bacteria are a contributing cause of stress-related mucosal inflammation, human peripheral blood monocyte-derived dendritic cells were stimulated by commensal bacterial strains. Both CRF and UCN1 were significantly augmented by Bacteroides vulgatus (B. vulgatus) and Fusobacterium varium (F. varium) at both the mRNA and protein levels. Thus, B. vulgatus and F. varium may be associated with stress-related intestinal disorders. |
| Publish Date |
2014-10-20 18:35 |
| Citation |
Koido S, Ohkusa T, Kan S, Takakura K, Saito K, Komita H, Ito Z, Kobayashi H, Takami S, Uchiyama K, Arakawa H, Ito M, Okamoto M, Kajihara M, Homma S, Tajiri H. Production of corticotropin-releasing factor and urocortin from human monocyte-derived dendritic cells is stimulated by commensal bacteria in intestine. World J Gastroenterol 2014; 20(39): 14420-14429 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i39/14420.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i39.14420 |
