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10/20/2014 6:36:00 PM | Browse: 1489 | Download: 1639
Publication Name World Journal of Gastroenterology
Manuscript ID 9821
Country/Territory Ireland
Received
2014-03-01 13:27
Peer-Review Started
2014-03-01 20:01
To Make the First Decision
2014-03-27 21:11
Return for Revision
2014-03-31 10:06
Revised
2014-04-18 00:00
Second Decision
2014-05-26 21:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-05-26 21:55
Articles in Press
2014-05-26 22:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-10-08 19:48
Publish the Manuscript Online
2014-10-20 18:35
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Topic Highlights
Article Title Irritable bowel syndrome: A microbiome-gut-brain axis disorder?
Manuscript Source Invited Manuscript
All Author List Paul J Kennedy, John F Cryan, Timothy G Dinan and Gerard Clarke
Funding Agency and Grant Number
Funding Agency Grant Number
Science Foundation Ireland SFI/12/RC/2272
Science Foundation Ireland 02/CE/B124
Science Foundation Ireland 07/CE/B1368
Health Research Board HRA_POR/2011/23
Brain and Behaviour Research Foundation 20771
Corresponding Author Gerard Clarke, PhD, 1.15 Biosciences Institute, Department of Psychiatry, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland. g.clarke@ucc.ie
Key Words Irritable bowel syndrome; Microbiome; Anxiety; Tryptophan; Abdominal pain; Gastrointestinal motility; Cognition
Core Tip A dysregulated gut-brain axis may be responsible for the main features of irritable bowel syndrome (IBS). However, the role of the gut microbiota is an underappreciated but critical node in this construct. Numerous clinical studies have documented various alterations in the composition of the gut microbiota in IBS, indicating defects in stability and diversity of this virtual organ. Manipulation of the gut microbiome influences the symptom profile in IBS and clear mechanisms have been elucidated to explain these interactions. This has important clinical implications and may offer hope for future treatment options to alleviate the suffering caused by this debilitating disorder.
Publish Date 2014-10-20 18:35
Citation Kennedy PJ, Cryan JF, Dinan TG, Clarke G. Irritable bowel syndrome: A microbiome-gut-brain axis disorder? World J Gastroenterol 2014; 20(39): 14105-14125
URL http://www.wjgnet.com/1007-9327/full/v20/i39/14105.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i39.14105
Full Article (PDF) WJG-20-14105.pdf
Full Article (Word) WJG-20-14105.doc
Manuscript File 9821-Review.docx
Answering Reviewers 9821-Answering reviewers.pdf
Copyright License Agreement 9821-Copyright assignment.pdf
Peer-review Report 9821-Peer review.pdf
Scientific Misconduct Check 9821-CrossCheck.jpg
Scientific Editor Work List 9821-Scientific editor work list.pdf