ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Oncology |
Manuscript Type |
Retrospective Study |
Article Title |
Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Hao-Jie Yang, Jing-Hang Jiang, Yu-Ting Yang, Xiang-Di Yang, Zhe Guo, Ya-Peng Qi, Feng-Hua Zeng, Ke-Lan Zhang, Neng-Zhi Chen, Bang-De Xiang and Le-Qun Li |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81260331 |
Key Laboratory for High-Incidence Tumor Prevention and Treatment, Ministry of Education |
GKE2015-ZZ05 |
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Corresponding Author |
Dr. Bang-De Xiang, Professor, Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, 71 Hedi Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. yhj894924067@163.com
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Key Words |
Cyclooxygenase-2; Hepatocellular carcinoma; Liver resection; Prognosis; Prostaglandin E1 receptor |
Core Tip |
We retrospectively reviewed the records of 116 patients with hepatocellular carcinoma (HCC) who underwent surgery between 2008 and 2011 at our hospital. Our results suggest that the factors associated with poor overall survival were alpha-fetoprotein > 400 ng/mL, tumor size ≥ 5 cm, and high prostaglandin E1 (EP1) receptor expression, but not high cyclooxygenase-2 (COX-2) expression. Disease-free survival did not differ significantly between patients with low or high levels of COX-2 or EP1. COX-2 immunoreactivity was significantly higher in well-differentiated HCC tissues (Edmondson grade?Ⅰ-Ⅱ) than in poorly differentiated tissues (Edmondson grade Ⅲ-Ⅳ) (p = 0.003). EP1 receptor immunoreactivity was significantly higher in poorly differentiated tissue than in well-differentiated tissue (p = 0.001).
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Publish Date |
2016-10-20 17:06 |
Citation |
Yang HJ, Jiang JH, Yang YT, Yang XD, Guo Z, Qi YP, Zeng FH, Zhang KL, Chen NZ, Xiang BD, Li LQ. Cyclooxygenase-2 expression is associated with initiation of hepatocellular carcinoma, while prostaglandin receptor-1 expression predicts survival. World J Gastroenterol 2016; 22(39): 8798-8805 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i39/8798.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i39.8798 |