| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Case Report |
| Article Title |
Polycystic kidney and hepatic disease 1 gene mutations in von Meyenburg complexes: Case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Su Lin, Tian-Yu Shang, Ming-Fang Wang, Jian Lin, Xiao-Jian Ye, Da-Wu Zeng, Jiao-Feng Huang, Nan-Wen Zhang, Yi-Long Wu and Yue-Yong Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Pilot Project of Fujian Science and Technology Department |
2015Y0057 |
| Fujian Medical Innovation Project |
2018-ZQN-54 |
| Science and Technology Project of Fujian Education Department |
JAT160211 |
|
| Corresponding Author |
Yue-Yong Zhu, MD, PhD, Professor, Liver Research Center, the First Affiliated Hospital, Fujian Medical University, Chazhong Road 20th, Taijiang District, Fuzhou 350005, Fujian Province, China. zhuyueyong@fjmu.edu.cn |
| Key Words |
Von Meyenburg complexes; Ductal plate malformations; PKHD1; Gene mutation; Fibrosis |
| Core Tip |
Von Meyenburg complexes (VMCs) are a rare type of ductal plate malformation. Although generally benign, VMCs have been found to correlate with malignant diseases and progress towards adenocarcinomas. Mutations of the PKHD1 gene have been demonstrated to cause autosomal recessive polycystic kidney disease, a type of ductal plate malformation. In this study, mutations of the PKHD1 gene located in exon 28 and exon 32, respectively, were identified in two Chinese VMCs families, with four VMCs patients reported in total. |
| Publish Date |
2018-09-07 01:56 |
| Citation |
Lin S, Shang TY, Wang MF, Lin J, Ye XJ, Zeng DW, Huang JF, Zhang NW, Wu YL, Zhu YY. Polycystic kidney and hepatic disease 1 gene mutations in von Meyenburg complexes: Case report. World J Clin Cases 2018; 6(9): 296-300 |
| URL |
http://www.wjgnet.com/2307-8960/full/v6/i9/296.htm |
| DOI |
http://dx.doi.org/10.12998/wjcc.v6.i9.296 |
