Publication Name	World Journal of Gastroenterology
Manuscript ID	53451
Country	Kazakhstan

Received	2019-12-19 18:09
Peer-Review Started	2019-12-19 18:09
To Make the First Decision
Return for Revision	2020-01-12 06:43
Revised	2020-03-10 09:57
Second Decision	2020-03-20 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-03-22 01:55
Articles in Press	2020-03-22 01:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-03-27 09:20
Publish the Manuscript Online	2020-03-28 13:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening
Manuscript Source	Invited Manuscript
All Author List	Dimitri Poddighe, Chiara Rebuffi, Annalisa De Silvestri and Cristina Capittini
ORCID	Author(s) ORCID Number Dimitri Poddighe http://orcid.org/0000-0001-6431-9334 Chiara Rebuffi http://orcid.org/0000-0001-6405-4989 Annalisa De Silvestri http://orcid.org/0000-0003-3128-8441 Cristina Capittini http://orcid.org/0000-0002-2204-8449
Funding Agency and Grant Number	Funding Agency Grant Number Nazarbayev University Faculty Development Competitive Research Grant 2020-2022 240919FD3912
Corresponding Author	Dimitri Poddighe, MD, MSc, Assistant Professor, Department of Medicine, School of Medicine, Nazarbayev University, Kerei-Zhanibek Street 5/1, Nur-Sultan 010000, Kazakhstan. dimitri.poddighe@nu.edu.kz
Key Words	Celiac disease; Children; HLA-DQB1*02; DQ2 heterodimer; Screening; Systematic review
Core Tip	It is well known that HLA-DQ genotyping is useful to assess the individual susceptibility to celiac disease (CD) with very high - if not absolute – discriminatory power: Indeed, it is very unlikely that individuals who do not carry specific HLA-DQ alleles coding MHC-DQ2 and MHC-DQ8 heterodimers, may develop CD. Here, we aim at providing further evidence of the specific epidemiological importance of HLA-DQB1*02 allele in the population of CD patients. Briefly, based on 38 original articles that we included in this systematic review (which provided a pool of 4945 HLA-DQ genotyped CD patients, overall), we could find a very high carrier frequency of the HLA-DQB1*02 allelic variant. Indeed, > 95%-96% of CD patients resulted to carry at least one copy of the HLA-DQB1*02 allele. This knowledge might be exploited to consider a cost-effective and widened screening approach: If a sustainable strategy could be implemented through a low-cost targeted genetic test for CD, an appropriate algorithm for serological screening in individuals resulting to be genetically predisposed to CD, might be considered.
Publish Date	2020-03-28 13:10
Citation	Poddighe D, Rebuffi C, De Silvestri A, Capittini C. Carrier frequency of HLA-DQB1*02 allele in patients affected with celiac disease: A systematic review assessing the potential rationale of a targeted allelic genotyping as a first-line screening. World J Gastroenterol 2020; 26(12): 1365-1381
URL	https://www.wjgnet.com/1007-9327/full/v26/i12/1365.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i12.1365

Full Article (PDF)	WJG-26-1365.pdf
Full Article (Word)	WJG-26-1365.docx
PRISMA 2009 Checklist	53451-PRISMA-2009-Checklist-revision.pdf
Manuscript File	53451-Review.docx
Answering Reviewers	53451-Answering reviewers.pdf
Audio Core Tip	53451-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	53451-Conflict-of-interest statement.pdf
Copyright License Agreement	53451-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	53451-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	53451-Language certificate.pdf
Peer-review Report	53451-Peer-review(s).pdf
Scientific Misconduct Check	53451-Scientific misconduct check.pdf
Scientific Editor Work List	53451-Scientific editor work list.pdf