| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Immune and microRNA responses to Helicobacter muridarum infection and indole-3-carbinol during colitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rasha Raheem Alkarkoushi, Yvonne Hui, Abbas S Tavakoli, Udai Singh, Prakash Nagarkatti, Mitzi Nagarkatti, Ioulia Chatzistamou, Marpe Bam and Traci L Testerman |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institutes of Health grant |
P20GM103641 |
|
| Corresponding Author |
Traci L Testerman, PhD, Assistant Professor, Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, No.6439 Garners Ferry Road, Columbia, SC 29209, United States. traci.testerman@uscmed.sc.edu |
| Key Words |
Helicobacter muridarum; MicroRNA; Immune; T regulatory cell; T helper 17 cell; Colitis |
| Core Tip |
The immune response to Helicobacter muridarum (H. muridarum), an enterohepatic Helicobacter species, mimics responses seen during chemically induced colitis and human inflammatory bowel disease (IBD) in terms of local and systemic cytokine responses and microRNA changes. Most microRNAs that are altered in IBD are also altered by H. muridarum infection with or without dextran sodium sulfate treatment. Furthermore, H. muridarum does not alter activity of an aryl hydrocarbon receptor agonist, indole-3-carbinol, a natural compound being explored as a treatment for IBD. Therefore, H. muridarum infection provides a viable model for predicting the effects of enterohepatic Helicobacter species on IBD. |
| Publish Date |
2020-08-28 15:06 |
| Citation |
Alkarkoushi RR, Hui Y, Tavakoli AS, Singh U, Nagarkatti P, Nagarkatti M, Chatzistamou I, Bam M, Testerman TL. Immune and microRNA responses to Helicobacter muridarum infection and indole-3-carbinol during colitis. World J Gastroenterol 2020; 26(32): 4763-4785 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i32/4763.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i32.4763 |
