| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Quelson Coelho Lisboa, Mateus Jorge Nardelli, Patrícia de Araújo Pereira, Débora Marques Miranda, Stephanie Nunes Ribeiro, Raissa Soares Neves Costa, Camila Azevedo Versiani, Paula Vieira Teixeira Vidigal, Teresa Cristina de Abreu Ferrari and Claudia Alves Couto |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação de Amparo à Pesquisa do Estado de Minas Gerais |
APQ-01603-13 |
|
| Corresponding Author |
Claudia Alves Couto, MD, PhD, Associate Professor, Departamento de Clínica Médica, Faculty of Medicine, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena 190, Belo Horizonte 30130100, Brazil. clalcouto@gmail.com |
| Key Words |
Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Genetic variation; Single nucleotide polymorphism; Genotype; Brazil |
| Core Tip |
The rs738409 C/G mutation in the PNPLA3 gene may be involved in the pathogenesis of Nonalcoholic fatty liver disease (NAFLD) in Brazilian population. We found association between the polymorphism and higher susceptibility to NAFLD occurrence, disease progression to nonalcoholic steatohepatitis, more severe histological activity scores and presence of liver fibrosis. The TM6SF2 gene variants were also evaluated in the Brazilian population, although they were not associated with NAFLD susceptibility and different histological forms. |
| Publish Date |
2020-10-24 02:27 |
| Citation |
Lisboa QC, Nardelli MJ, Pereira PA, Miranda DM, Ribeiro SN, Costa RSN, Versiani CA, Vidigal PVT, Ferrari TCA, Couto CA. PNPLA3 and TM6SF2 polymorphisms in Brazilian patients with nonalcoholic fatty liver disease. World J Hepatol 2020; 12(10): 792-806 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i10/792.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i10.792 |
