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Articles Published Processes
1/30/2021 10:10:27 AM | Browse: 419 | Download: 911
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Received |
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2020-10-29 13:10 |
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Peer-Review Started |
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2020-10-29 13:11 |
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To Make the First Decision |
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Return for Revision |
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2020-11-20 05:08 |
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Revised |
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2020-12-02 01:10 |
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Second Decision |
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2020-12-14 06:57 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-12-16 20:04 |
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Articles in Press |
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2020-12-16 20:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-12-21 00:53 |
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Typeset the Manuscript |
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2021-01-27 16:14 |
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Publish the Manuscript Online |
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2021-01-30 10:10 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Case Report |
| Article Title |
Heterochronic triple primary malignancies with Epstein-Barr virus infection and TP53 mutation: A case report and review of literature
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Xia Peng, Xin Liu, Qi-Feng Wang, Xiao-Yan Zhou, Zhi-Guo Luo and Xi-Chun Hu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xi-Chun Hu, MD, PhD, Professor, Department of Medical Oncology, Fudan University Shanghai Cancer Center, NO. 270 Dongan Road, Xuhui District, Shanghai 200032, China. huxichun2017@163.com |
| Key Words |
Multiple primary malignant neoplasms; Epstein-Barr virus infection; Epstein-Barr virus-encoded RNA; TP53 mutation; Etiology; Case report |
| Core Tip |
The occurrence of triple heterochronic primary malignancies associated with Epstein-Barr virus (EBV) infection and genetic mutations is an extremely rare event. To the best of our knowledge, this is the first case of a 39-year-old male patient with triple heterochronic primary tumors including EBV-associated stomach cancer and nasopharyngeal cancer and TP53 mutant rectal carcinoma in the literature, and appropriate therapy for each primary cancer led to his good clinical outcome. This case further confirms the value of precision medicine; only a precise diagnosis can lead to appropriate treatment and good prognosis. Further research is needed to elucidate the role of EBV infection and the TP53 gene in the carcinogenesis of multiple primary malignant neoplasms. |
| Publish Date |
2021-01-30 10:10 |
| Citation |
Peng WX, Liu X, Wang QF, Zhou XY, Luo ZG, Hu XC. Heterochronic triple primary malignancies with Epstein-Barr virus infection and TP53 mutation: A case report and review of literature. World J Clin Cases 2021; 9(5): 1184-1195 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i5/1184.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i5.1184 |
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