| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Case Report |
| Article Title |
Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Meng Zhang, Ling Jin, Yan-Long Duan, Jing Yang, Shuang Huang, Mei Jin, Guang-Hua Zhu, Chao Gao, Yi Liu, Nan Zhang, Chun-Ju Zhou, Zi-Fen Gao, Qin-Long Zheng, Dong Chen and Yong-Hong Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority |
XTZD20180204 |
|
| Corresponding Author |
Yong-Hong Zhang, MD, Doctor, Beijing Key Laboratory of Pediatric Hematology Oncology, National Discipline of Pediatrics, Ministry of Education, MOE Key Laboratory of Major Diseases in Children, Hematology Oncology Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, No. 56 Nanlishi Road, Beijing 100045, China. yhzhang58@hotmail.com |
| Key Words |
Pediatric; Anaplastic lymphoma kinase-positive large B-cell lymphoma; CLTC-ALK; PGS1-CLTC; Hematopoietic stem cell transplantation; Alectinib |
| Core Tip |
Anaplastic lymphoma kinase-positive (ALK+) large B-cell lymphoma (LBCL) is a rare subtype of diffuse LBCL and is particularly rare in pediatric non-Hodgkin lymphoma patients. The modified LMB89 Group C regimen is effective for ALK+LBCL. Since bone marrow failure occurs after relapse, the patient cannot tolerate intensive chemotherapy, ALK inhibitors combined with low-dose chemotherapy could be considered, and there is still hope for complete remission 2. It is advised that allogeneic hematopoietic stem cell transplantation should be performed as soon as possible after remission. |
| Publish Date |
2021-05-26 09:58 |
| Citation |
Zhang M, Jin L, Duan YL, Yang J, Huang S, Jin M, Zhu GH, Gao C, Liu Y, Zhang N, Zhou CJ, Gao ZF, Zheng QL, Chen D, Zhang YH. Diagnosis and treatment of pediatric anaplastic lymphoma kinase-positive large B-cell lymphoma: A case report. World J Clin Cases 2021; 9(17): 4268-4278 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i17/4268.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i17.4268 |
