Publication Name	World Journal of Clinical Cases
Manuscript ID	70792
Country	China

Received	2021-08-15 02:16
Peer-Review Started	2021-08-15 02:21
To Make the First Decision
Return for Revision	2021-10-20 20:50
Revised	2021-10-30 13:49
Second Decision	2022-01-25 03:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-26 22:15
Articles in Press	2022-01-26 22:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-02-19 14:56
Publish the Manuscript Online	2022-03-11 00:39

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Geriatrics & Gerontology
Manuscript Type	Case Report
Article Title	Idarucizumab reverses dabigatran-induced anticoagulation in treatment of gastric bleeding: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Jia, Shao-Hua Wang, Na-Juan Cui, Quan-Xi Liu, Wei Wang, Xue Li, Ya-Mei Gu and Yan Zhu
ORCID	Author(s) ORCID Number Yu Jia http://orcid.org/0000-0002-1743-4943 Shao-Hua Wang http://orcid.org/0000-0002-9085-5218 Na-Juan Cui http://orcid.org/0000-0002-7867-6153 Quan-Xi Liu http://orcid.org/0000-0002-6526-2840 Wei Wang http://orcid.org/0000-0001-5057-5433 Xue Li http://orcid.org/0000-0001-8880-1133 Ya-Mei Gu http://orcid.org/0000-0001-7173-1183 Yan Zhu http://orcid.org/0000-0001-5906-1412
Funding Agency and Grant Number
Corresponding Author	Yan Zhu, MS, Attending Doctor, gastroenterology, Hospital of Integrated Traditional Chinese and Western Medicine, No.3 East Yongding Road, Haidian District, Beijing 100039, China. zy815925@163.com
Key Words	Idarucizumab; Dabigatran; Gastric bleeding; Atrial fibrillation; Case report
Core Tip	The anticoagulatory effect of dabigatran resolves completely after five half-lives, which is approximately 2.5-3.5 d after the last dose for patients with normal renal function. Thrombin time (TT) is sensitive to the effects of dabigatran and can be prolonged even with trivial amounts of the drug. This patient exhibited persistent bleeding in the normal coagulation test (except for TT), possibly due to the anticoagulatory effects of the drug administered 4 days after the last dose for her renal insufficiency. Therefore, idarucizumab was administered for hemostasis, thus stopping the bleeding. This case highlights the importance of regular monitoring of renal function in older patients.
Publish Date	2022-03-11 00:39
Citation	Jia Y, Wang SH, Cui NJ, Liu QX, Wang W, Li X, Gu YM, Zhu Y. Idarucizumab reverses dabigatran-induced anticoagulation in treatment of gastric bleeding: A case report. World J Clin Cases 2021; 10(8): 2537-2542
URL	https://www.wjgnet.com/2307-8960/full/v10/i8/2537.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i8.2537

Full Article (PDF)	WJCC-10-2537.pdf
Full Article (Word)	WJCC-10-2537.docx
CARE Checklist–2016	70792-CARE-Checklist–2016-revision.pdf
Manuscript File	70792_Auto_Edited.docx
Answering Reviewers	70792-Answering reviewers.pdf
Audio Core Tip	70792-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	70792-Conflict-of-interest statement.pdf
Copyright License Agreement	70792-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	70792-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	70792-Language certificate.pdf
Peer-review Report	70792-Peer-review(s).pdf
Scientific Misconduct Check	70792-Bing Wu YXJ-2.png
Scientific Editor Work List	70792-Scientific editor work list.pdf