| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Observational Study |
| Article Title |
Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Feng Luo, Yu-Ting Jiao, Xiao-Ling Lin, Ying Zhao, Sheng-Bo Wang, Jian Shen, Jie Deng, Yu-Feng Ye, Ze-Ping Han, Fang-Mei Xie, Jin-Hua He and Yu Wan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Program of Panyu Central Hospital |
PY-2023-003 |
| Science and Technology Program of Panyu |
2020-Z04-054 |
| Science and Technology Project of the Guangzhou Health Commission |
20211A011114 |
| Science and Technology Program of Guangzhou |
202002020023 |
| General University Youth Innovative Talent Project of Guangdong Province |
2022KQNCX281 |
| Guangdong Provincial Key Field Special Project for Ordinary Colleges and Universities |
2023ZDZX2097 |
| Foshan Engineering Technology Research Center for Prepared Food Processing and Quality Evaluation |
2022-KJZX113 |
|
| Corresponding Author |
Wen-Feng Luo, MS, PhD, Assistant Professor, Doctor, Central Laboratory of Panyu Central Hospital, Guangzhou Panyu Central Hospital, No. 8 East Fuyu Road, Qiaonan Street, Panyu District, Guangzhou 511400, Guangdong Province, China. luowenfeng163@163.com |
| Key Words |
Colorectal cancer; Syndecan-2; DNA methylation; Chinese population |
| Core Tip |
A high-risk Chinese cohort composed of 1130 individuals 40-79 years of age was selected for evaluation using the fecal syndecan-2 methylation (mSDC2) test. Sensitivity and specificity to colorectal cancer (CRC), advanced adenoma and advanced colorectal neoplasia were quantified. High-risk factors for the incidence of colorectal lesions were analyzed; a logistic regression model was subsequently constructed to better reflect the efficacy of fecal mSDC2 testing. The results of this CRC screening study revealed that offering patients a combination of fecal mSDC2 testing and colonoscopy is ideal for facilitating early detection of CRC among a high-risk Chinese population. |
| Publish Date |
2024-04-11 02:23 |
| Citation |
Luo WF, Jiao YT, Lin XL, Zhao Y, Wang SB, Shen J, Deng J, Ye YF, Han ZP, Xie FM, He JH, Wan Y. Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population. World J Gastrointest Oncol 2024; 16(4): 1361-1373 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i4/1361.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i4.1361 |
