Publication Name	World Journal of Meta-Analysis
Manuscript ID	16292
Country

Received	2015-01-08 10:53
Peer-Review Started	2015-01-10 14:00
To Make the First Decision	2015-06-03 14:38
Return for Revision	2015-06-04 15:46
Revised	2015-06-25 00:00
Second Decision	2015-07-17 08:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-27 17:01
Articles in Press	2015-07-27 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-08-03 22:47
Typeset the Manuscript	2015-10-19 21:25
Publish the Manuscript Online	2015-10-30 08:27

ISSN	2308-3840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Allergy
Manuscript Type	Meta-Analysis
Article Title	How to impute study-specific standard deviations in meta-analyses of skewed continuous endpoints?
Manuscript Source	Unsolicited Manuscript
All Author List	Teresa Greco, Giuseppe Biondi-Zoccai, Marco Gemma, Claude Guérin, Alberto Zangrillo and Giovanni Landoni
Funding Agency and Grant Number
Corresponding Author	Teresa Greco, MSc, Laboratorio di Statistica Medica, Biometria ed Epidemiologia “G. A. Maccacaro”, Dipartimento di Scienze Cliniche e di Comunità, University of Milan, Via Festa del Perdono 7, 20133 Milan, Italy. greco.teresa@hotmail.it
Key Words	Imputation; Interquartile range; Meta-analysis; Randomized controlled trial; Standard deviation
Core Tip	Meta-analyses of continuous endpoints are generally supposed to deal with normally distributed data and the pooled estimate of the treatment effect relies on means and standard deviations. However, if the outcome distribution is skewed, some authors correctly report the median together with the corresponding quartiles. In the present work, we compared methods for the approximation of means and standard deviations when only medians with quartiles are provided. Our results demonstrate that meta-analytic estimates are not significantly affected by approximating the missing values of mean and standard deviation with the correspondent values for median and interquartile range.
Publish Date	2015-10-30 08:27
Citation	Greco T, Biondi-Zoccai G, Gemma M, Guérin C, Zangrillo A, Landoni G. How to impute study-specific standard deviations in meta-analyses of skewed continuous endpoints? World J Meta-Anal 2015; 3(5): 215-224
URL	http://www.wjgnet.com/2308-3840/full/v3/i5/215.htm
DOI	http://dx.doi.org/10.13105/wjma.v3.i5.215

Full Article (PDF)	WJMA-3-215.pdf
Full Article (Word)	WJMA-3-215.doc
Manuscript File	16292-Review.docx
Answering Reviewers	16292-Answering reviewers.pdf
Audio Core Tip	16292-Audio core tip.wav
Biostatistics Review Certificate	16292-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16292-Conflict-of-interest statement.pdf
Copyright License Agreement	16292-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	16292-Language certificate.pdf
Supplementary Material	Supplementary_Material_20150108105126.docx
Peer-review Report	16292-Peer-review(s).pdf
Scientific Misconduct Check	16292-Scientific misconduct check.pdf
Scientific Editor Work List	16292-Scientific editor work list.pdf