Publication Name	World Journal of Hepatology
Manuscript ID	31439
Country	Japan

Received	2016-11-17 08:58
Peer-Review Started	2016-11-17 17:15
To Make the First Decision	2017-02-04 14:28
Return for Revision	2017-02-09 10:59
Revised	2017-02-11 14:57
Second Decision	2017-04-14 10:48
Accepted by Journal Editor-in-Chief	2017-04-14 11:36
Accepted by Executive Editor-in-Chief	2017-04-24 17:29
Articles in Press	2017-04-24 17:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-05-15 00:24
Publish the Manuscript Online	2017-05-17 06:29

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Image quality and diagnostic performance of free-breathing diffusion-weighted imaging for hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yukihisa Takayama, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Nobuhiro Fujita, Ken Shirabe, Atsushi Takemura and Hiroshi Honda
Funding Agency and Grant Number
Corresponding Author	Akihiro Nishie, MD, PhD, Associated professor, Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. anishie@radiol.med.kyushu-u.ac.jp
Key Words	diffusion weighted-imaging; liver; magnetic resonance imaging; hepatocellular carcinoma; free-breathing technique
Core Tip	This retrospective study evaluated the image quality of free-breathing diffusion-weighted imaging (FB-DWI) of the liver and its diagnostic performance for hepatocellular carcinoma compared with respiratory-triggered DWI. The free-breathing technique is widely believed to be inappropriate for body DWI because motion artifact causes decreased image quality. How­ever, after a modification of imaging parameters, FB-DWI showed better image quality without significantly reducing the signal-to-noise ratio of the normal liver parenchyma and the lesion-to-nonlesion contrast-to-noise ratio com­pared to respiratory-triggering-DWI. As a result, the improvement of the image quality of FB-DWI contributed to an increased rate of detection of hepatocellular carcinoma.
Publish Date	2017-05-17 06:29
Citation	Takayama Y, Nishie A, Asayama Y, Ishigami K, Kakihara D, Ushijima Y, Fujita N, Shirabe K, Takemura A, Honda H. Image quality and diagnostic performance of free-breathing diffusion-weighted imaging for hepatocellular carcinoma. World J Hepatol 2017; 9(14): 657-666
URL	http://www.wjgnet.com/1948-5182/full/v9/i14/657.htm
DOI	http://dx.doi.org/10.4254/wjh.v9.i14.657

Full Article (PDF)	WJH-9-657.pdf
Full Article (Word)	WJH-9-657.doc
Manuscript File	31439-Review.docx
Answering Reviewers	31439-Answering reviewers.pdf
Audio Core Tip	31439-Audio core tip.mp3
Biostatistics Review Certificate	31439-Biostatistics statement.pdf
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20161116152736.docx
Conflict-of-Interest Disclosure Form	31439-Conflict-of-interest statement.pdf
Copyright License Agreement	31439-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	31439-Informed consent statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	Institutional_Animal_Care_and_Use_Committee_Statement_20161116152955.docx
Institutional Review Board Approval Form or Document	31439-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	31439-Language certificate.pdf
Peer-review Report	31439-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	31439-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	31439-Scientific misconduct check.pdf
Scientific Editor Work List	31439-Scientific editor work list.pdf