Publication Name	World Journal of Cardiology
Manuscript ID	32517
Country	United States

Received	2017-01-12 08:56
Peer-Review Started	2017-01-16 08:39
First Decision by Editorial Office Director
Return for Revision	2017-04-17 15:27
Revised	2017-06-22 15:27
Publication Fee Transferred
Second Decision by Editor	2017-07-18 09:28
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2017-07-24 05:07
Articles in Press	2017-07-24 05:07
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-08-18 07:57
Publish the Manuscript Online	2017-08-24 04:57

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner
Manuscript Source	Invited Manuscript
All Author List	Danielle R Bruns, Alexander R Ghincea, Christian V Ghincea, Yasu-Taka Azuma, Peter A Watson, Michael V Autieri and Lori A Walker
Funding Agency and Grant Number	Funding Agency Grant Number University of Colorado-Denver Center for Women’s Health Research To Walker LA NIH NHLBI HL007822-19 (to Bruns DR) NIH NHLBI HL117724 (to Autieri MV) NIH NHLBI HL115575 (to Autieri MV)
Corresponding Author	Lori A Walker, PhD, Division of Cardiology, Department of Medicine, University of Colorado-Denver, 12700 E. 19th Ave, Aurora, CO 80045, United States. lori.walker@ucdenver.edu
Key Words	Cardiac dysfunction; Sex differences; Heart failure; Interleukin-19
Core Tip	Heart failure (HF) is a sexually dimorphic disease. In a female-dominant model of HF, the do-minant negative cyclic AMP response-element binding protein (dnCREB) mouse, female mice show accelerated cardiac morbidity and mortality alongside downregulated interleukin-19 (IL-19) expression, while male mice maintain IL-19 expression and are protected against cardiac dysfunction. We generated a novel double transgenic mouse with dnCREB and IL-19 knockout to test the hypothesis that IL-19 is cardioprotective. We show accelerated cardiac morbidity only in male mice, supporting the hypothesis that IL-19 is a sex-specific cardioprotective cytokine.
Publish Date	2017-08-24 04:57
Citation	Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA. Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. World J Cardiol 2017; 9(8): 673-684
URL	http://www.wjgnet.com/1949-8462/full/v9/i8/673.htm
DOI	http://dx.doi.org/10.4330/wjc.v9.i8.673

Full Article (PDF)	WJC-9-673.pdf
Full Article (Word)	WJC-9-673.doc
Manuscript File	32517-Review.docx
Answering Reviewers	32517-Answering reviewers.pdf
Audio Core Tip	32517-Audio core tip.mp3
Biostatistics Review Certificate	32517-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	32517-Conflict-of-interest statement.pdf
Copyright License Agreement	32517-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	32517-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	32517-Institutional review board statement.pdf
Peer-review Report	32517-Peer-review(s).pdf
Scientific Misconduct Check	32517-Scientific misconduct check.pdf
Scientific Editor Work List	32517-Scientific editor work list.pdf