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8/24/2017 8:18:40 AM | Browse: 1292 | Download: 1227
Publication Name World Journal of Stem Cells
Manuscript ID 33488
Country/Territory China
Received
2017-02-13 14:17
Peer-Review Started
2017-02-15 09:09
To Make the First Decision
2017-03-08 09:46
Return for Revision
2017-03-10 17:42
Revised
2017-03-18 07:30
Second Decision
2017-07-06 09:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-07-17 06:10
Articles in Press
2017-07-17 06:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-18 07:54
Publish the Manuscript Online
2017-08-24 02:02
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Randomized Controlled Trial
Article Title Phase Ⅰ/Ⅱ randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke
Manuscript Source Invited Manuscript
All Author List Kam Sze Tsang, Chi Ping Stephanie Ng, Xian Lun Zhu, George Kwok Chu Wong, Gang Lu, Anil Tejbhan Ahuja, Ka Sing Lawrence Wong, Ho Keung Ng and Wai Sang Poon
Funding Agency and Grant Number
Corresponding Author Wai Sang Poon, MD, Division of Neurosurgery, Department of Surgery, the Chinese University of Hong Kong, Prince of Wales Hospital, 30-32, Ngan Shing Road, Shatin, Hong Kong NA, China. wpoon@cuhk.edu.hk
Key Words Stroke; Intracerebral haemorrhage; Central nervous system; Mesenchymal stem cells; Cell therapy
Core Tip Contemporary treatments are ineffective in restoring lost neurological functions after stroke. Many stroke patients were noted to have lesions close to the sub-ventricular zone. The likely beneficial effects of mesenchymal stem cell (MSC) treatment might correlate with the spatial lesion, not part of the sub-ventricular zone where endogenous neurogenesis persists during adulthood, and indirect chaperon effects of MSC promote endogenous neuro-regeneration. We administered MSC intravenously to patients having severe neurological disability and presenting stable baseline scores one year after the onset of intracerebral haemorrhage to eliminate confounding attributes to the observation of MSC-me¬diated neurological recovery.
Publish Date 2017-08-24 02:02
Citation Tsang KS, Ng CPS, Zhu XL, Wong GKC, Lu G, Ahuja AT, Wong KSL, Ng HK, Poon WS. Phase Ⅰ/Ⅱ randomized controlled trial of autologous bone marrow-derived mesenchymal stem cell therapy for chronic stroke. World J Stem Cells 2017; 9(8): 133-143
URL http://www.wjgnet.com/1948-0210/full/v9/i8/133.htm
DOI http://dx.doi.org/10.4252/wjsc.v9.i8.133
Full Article (PDF) WJSC-9-133.pdf
Full Article (Word) WJSC-9-133.doc
Manuscript File 33488-Review.docx
Answering Reviewers 33488-Answering reviewers.pdf
Audio Core Tip 33488-Audio core tip.m4a
Biostatistics Review Certificate 33488-Biostatistics statement.pdf
Clinical Trial Registration Statement 33488-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 33488-Conflict-of-interest statement.pdf
Copyright License Agreement 33488-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) 33488-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 33488-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 33488-Language certificate.pdf
Supplementary Material 33488-Supplementary material.docx
Peer-review Report 33488-Peer-review(s).pdf
Scientific Misconduct Check 33488-Scientific misconduct check.pdf
Scientific Editor Work List 33488-Scientific editor work list.pdf