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4/23/2019 9:03:59 AM | Browse: 594 | Download: 671
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Received |
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2019-02-06 03:20 |
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Peer-Review Started |
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2019-02-06 14:26 |
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To Make the First Decision |
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2019-03-06 01:59 |
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Return for Revision |
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2019-03-06 02:17 |
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Revised |
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2019-03-20 19:10 |
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Second Decision |
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2019-03-22 08:34 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-03-25 04:39 |
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Articles in Press |
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2019-03-25 04:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-04-17 00:55 |
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Publish the Manuscript Online |
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2019-04-18 05:48 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Enrique Rozengurt and Guido Eibl |
| Funding Agency and Grant Number |
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| Corresponding Author |
Guido Eibl, MD, Director, Director, Professor, Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, 72-236 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, United States. geibl@mednet.ucla.edu |
| Key Words |
Pancreatic cancer; Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif; Oncogenic Kras; Obesity; Signaling network and loops |
| Core Tip |
The identification of signaling networks that underlie risk factor promoted pancreatic cancer development and progression is of paramount importance to prevent or intercept this lethal disease. Accumulating evidence suggests that several core signaling pathways downstream of oncogenic Kras, augmented by environmental conditions, e.g., obesity, converge on Yes-associated protein (YAP) and WW-domain-containing transcriptional co-activator with PDZ-binding motif (TAZ), transcriptional co-activators in the Hippo pathway. Statins and metformin, widely used Food and Drug Administration-approved drugs, show great promise to intercept this disease by disrupting or inhibiting this amplifying network at multiple points converging onto YAP/TAZ. |
| Publish Date |
2019-04-18 05:48 |
| Citation |
Rozengurt E, Eibl G. Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. World J Gastroenterol 2019;25(15): 1797-1816 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i15/1797.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i15.1797 |
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