| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Stem cells from human exfoliated deciduous teeth ameliorate concanavalin A-induced autoimmune hepatitis by protecting hepatocytes from apoptosis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Kun Zhou, Ling-Su Zhu, Hua-Ming Huang, Sheng-Jie Cui, Ting Zhang, Yan-Heng Zhou and Rui-Li Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The National Natural Science Foundation of China |
81970940 |
| Beijing Natural Science Foundation |
7182182 |
| The National Science and Technology Major Project of the Ministry of Science and Technology of China |
2018ZX10302207 |
| The National Natural Science Foundation of China |
81600865 |
|
| Corresponding Author |
Rui-Li Yang, DDS, PhD, Assistant Professor, Department of Orthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, No. 22 Zhongguancun South Avenue, Beijing 100081, China. ruiliyangabc@163.com |
| Key Words |
Autoimmune hepatitis; Stem cells from human exfoliated deciduous teeth; Concanavalin A; Apoptosis; Nuclear factor-kappa B |
| Core Tip |
Autoimmune hepatitis poses an enhancing global burden, underscoring the need to identify novel treatments. To determine the effects of stem cells from human exfoliated deciduous teeth (SHED) on concanavalin A (ConA)-induced autoimmune hepatitis, we pretreated ConA-induced hepatitis mice with SHED. SHED blocked increased expression of alanine aminotransferase and aspartate aminotransferase, as well as prevented aberrant histopathological liver architecture due to infiltration of CD3+, CD4+, tumor necrosis-alpha+ and interferon-gamma+ inflammatory cells. ConA upregulates nuclear factor-kappa B-activated tumor necrosis-alpha and interferon-gamma expression, inducing hepatocyte apoptosis and acute liver injury. SHED administration protects hepatocytes from apoptosis, providing a potential treatment for hepatitis and acute hepatic injury. |
| Publish Date |
2020-12-27 05:30 |
| Citation |
Zhou YK, Zhu LS, Huang HM, Cui SJ, Zhang T, Zhou YH, Yang RL. Stem cells from human exfoliated deciduous teeth ameliorate concanavalin A-induced autoimmune hepatitis by protecting hepatocytes from apoptosis. World J Stem Cells 2020; 12(12): 1623-1639 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i12/1623.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i12.1623 |
