BPG is committed to discovery and dissemination of knowledge
Featured Articles
3/21/2023 8:33:44 AM | Browse: 205 | Download: 715
Publication Name World Journal of Gastrointestinal Pathophysiology
Manuscript ID 82233
Country/Territory Japan
Received
2022-12-11 13:53
Peer-Review Started
2022-12-11 13:55
To Make the First Decision
Return for Revision
2023-02-08 07:18
Revised
2023-02-19 18:57
Second Decision
2023-03-15 02:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-03-15 09:03
Articles in Press
2023-03-15 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-03-20 05:05
Publish the Manuscript Online
2023-03-21 03:50
ISSN 2150-5330 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Case Control Study
Article Title Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand
Manuscript Source Unsolicited Manuscript
All Author List Gyokukou You, Lu Zeng, Hideaki Tanaka, Emi Ohta, Takahiro Fujii, Kazuhiko Ohshima, Masakazu Tanaka, Nobuyuki Hamajima, Chutiwan Viwatthanasittiphong, Mantana Muangphot, Dhiraphol Chenvidhya, A Jedpiyawongse, Banchob Sripa, Masanao Miwa and Satoshi Honjo
Funding Agency and Grant Number
Funding Agency Grant Number
Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 21406011
Corresponding Author Satoshi Honjo, MD, MSc, PhD, Chief Doctor, Senior Researcher, Department of Paediatirics, National Hospital Organization, Fukuoka National Hospital, 1-39-4 Yakatabaru, Minami-ku, Fukuoka 811-1394, Fukuoka, Japan. satoshihonjo@hotmail.com
Key Words Opisthorchis; Glutathione transferase; Cytochrome P-450 CYP2E1; Case-control study
Core Tip Cholangiocarcinoma (CCA) is an intractable cancer, and its prevalence in northeastern Thailand is the highest worldwide. An inflammatory condition produced by infection with the liver fluke Opisthorchis viverrini (OV) has been associated with CCA risk, but the susceptibility of individuals has not been fully examined. Our study revealed that persons with the GSTT1 wild-type and CYP2E1 c1/c2 + c2/c2 genotype had an increased risk for developing CCA (OR = 3.33, 95%CI: 1.23-9.00). Therefore, both gene-gene interactions and OV infection should be considered as risk factors for cholangiocarcinogenesis.
Publish Date 2023-03-21 03:50
Citation You G, Zeng L, Tanaka H, Ohta E, Fujii T, Ohshima K, Tanaka M, Hamajima N, Viwatthanasittiphong C, Muangphot M, Chenvidhya D, Jedpiyawongse A, Sripa B, Miwa M, Honjo S. Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand. World J Gastrointest Pathophysiol 2023; 14(2): 21-33
URL https://www.wjgnet.com/2150-5330/full/v14/i2/21.htm
DOI https://dx.doi.org/10.4291/wjgp.v14.i2.21
Full Article (PDF) WJGP-14-21.pdf
Full Article (Word) WJGP-14-21.docx
Manuscript File 82233_Auto_Edited-JLW.docx
Answering Reviewers 82233-Answering reviewers.pdf
Audio Core Tip 82233-Audio core tip.mp3
Biostatistics Review Certificate 82233-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 82233-Conflict-of-interest statement.pdf
Copyright License Agreement 82233-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 82233-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 82233-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 82233-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 82233-Language certificate.pdf
Peer-review Report 82233-Peer-review(s).pdf
Scientific Misconduct Check 82233-Bing-Liu GL-2.png
Scientific Editor Work List 82233-Scientific editor work list.pdf