Publication Name	World Journal of Biological Chemistry
Manuscript ID	82942
Country	Brazil

Received	2022-12-30 21:47
Peer-Review Started	2022-12-30 21:49
To Make the First Decision
Return for Revision	2023-04-13 08:00
Revised	2023-04-30 17:49
Second Decision	2023-07-03 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-07-03 10:02
Articles in Press	2023-07-03 10:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-06-30 07:58
Typeset the Manuscript	2023-07-19 00:29
Publish the Manuscript Online	2023-07-25 06:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Chemistry, Medicinal
Manuscript Type	Basic Study
Article Title	In silico evidence of Remdesivir action in blood coagulation cascade modulation in COVID-19 treatment
Manuscript Source	Invited Manuscript
All Author List	Luis Gustavo Pagliarin, Lucca Miketen de Oliveira, Valentina Nunes Fontoura dos Anjos, Cristiano de Bem Torquato de Souza, Gabrielle Caroline Peiter, Cinthia Façanha Wendel, Anderson Dillmann Groto, Fabrício Freire de Melo and Kádima Nayara Teixeira
Funding Agency and Grant Number
Corresponding Author	Kádima Nayara Teixeira, PhD, Professor, Campus Toledo, Universidade Federal do Paraná, Max Planck 3796, Toledo 85.919-899, Paraná, Brazil. kadimateixeira@ufpr.br
Key Words	Clotting factors; Coagulating blood cascade; COVID-19 treatment; Remdesivir; SARS-CoV-2
Core Tip	In the initial period of the emergence of coronavirus disease 2019, bioinformatics tools filled the need for rapid knowledge about the severe acute respiratory syndrome coronavirus 2 and research in search of drug treatment, since experimental research takes time that was not available. Bioinformatics continues to be used for the same purpose in this study, remembering that this methodology does not rule out either in vivo or in vitro testing.
Publish Date	2023-07-25 06:07
Citation	Pagliarin LG, de Oliveira LM, dos Anjos VNF, de Souza CBT, Peiter GC, Façanha Wendel C, Dillmann Groto A, Freire de Melo F, Teixeira KN. In silico evidence of Remdesivir action in blood coagulation cascade modulation in COVID-19 treatment. World J Biol Chem 2023; 14(4): 72-83
URL	https://www.wjgnet.com/1949-8454 /full/v14/i4/72.htm
DOI	https://dx.doi.org/10.4331/wjbc.v14.i4.72

Full Article (PDF)	WJBC-14-72-with-cover.pdf
Full Article (Word)	WJBC-14-72.docx
Manuscript File	82942_Auto_Edited-LJH_WangTQ-JLW.docx
Answering Reviewers	82942-Answering reviewers.pdf
Audio Core Tip	82942-Audio core tip.aac
Biostatistics Review Certificate	82942-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	82942-Conflict-of-interest statement.pdf
Copyright License Agreement	82942-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	82942-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	82942-Language certificate.pdf
Peer-review Report	82942-Peer-review(s).pdf
Scientific Misconduct Check	82942-Bing-Liu JH-2.png
Scientific Misconduct Check	82942-CrossCheck.png
Scientific Editor Work List	82942-Scientific editor work list.pdf
CrossCheck Report	82942-CrossCheck report.pdf