Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	84149
Country	Egypt

Received	2023-02-27 22:36
Peer-Review Started	2023-02-27 22:40
To Make the First Decision
Return for Revision	2023-03-15 03:32
Revised	2023-03-16 00:50
Second Decision	2023-04-20 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-04-20 07:48
Articles in Press	2023-04-20 07:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-06-02 06:53
Publish the Manuscript Online	2023-06-08 09:24

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Observational Study
Article Title	Evaluation of children and adults with post-COVID-19 persistent smell, taste and trigeminal chemosensory disorders: A hospital based study
Manuscript Source	Unsolicited Manuscript
All Author List	Sherifa Ahmed Hamed, Eman Bahaa KamalEldeen and Mohamed Azzam Abdel-Razek Ahmed
Funding Agency and Grant Number
Corresponding Author	Sherifa Ahmed Hamed, MD, Professor, Department of Neurology and Psychiatry, Assiut University, Faculty of Medicine, Assiut University street, Assiut 71516, Assiut, Egypt. hamedsherifa@aun.edu.eg
Key Words	Post-COVID-19 complications; Anosmia; Ageusia; Trigeminal sensory loss; Parosmia; Quality of life
Core Tip	Smell loss is the most frequent acute manifestation of coronavirus disease 2019 (COVID-19) infection with an estimated prevalence of 40%-86% in adults and 16%-20% in children. Smell disorders (loss or distortion) are also the most frequent long-lasting complications of COVID-19 infection with an estimated prevalence of 20%-40% in adults. Compared to smell, taste disorders are less frequent acute manifestation of viral infection (occurring in 10%-42% of adults) and long-lasting complications of COVID-19 infection. Reports about the prevalence and prognosis of these disorders in children are few or even lacking compared to adults. Also the mechanisms and treatment of these persistent disorders are still challenges. Evidence from experimental studies suggested that injury and degeneration of the neuronal olfactory and gustatory sensory epithelia by severe peripheral viral infection and its immunopathology and the delay or lack of neuronal regeneration might contribute to these disorders. Here, we tried to determine the predictors for persistent disorders and distinguish their differences in children compared to adults.
Publish Date	2023-06-08 09:24
Citation	Hamed SA, Kamal-Eldeen EB, Ahmed MAA. Evaluation of children and adults with post-COVID-19 persistent smell, taste and trigeminal chemosensory disorders: A hospital based study. World J Clin Pediatr 2023; 12(3): 133-150
URL	https://www.wjgnet.com/2219-2808/full/v12/i3/133.htm
DOI	https://dx.doi.org/10.5409/wjcp.v12.i3.133

Full Article (PDF)	WJCP-12-133-with-cover.pdf
Full Article (Word)	WJCP-12-133.docx
STROBE Statement	84149-STROBE-Statement-revision.pdf
Manuscript File	84149_Auto_Edited-JLW.docx
Answering Reviewers	84149-Answering reviewers.pdf
Audio Core Tip	84149-Audio core tip.m4a
Biostatistics Review Certificate	84149-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	84149-Conflict-of-interest statement.pdf
Copyright License Agreement	84149-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	84149-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	84149-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	84149-Language certificate.pdf
Peer-review Report	84149-Peer-review(s).pdf
Scientific Misconduct Check	84149-Bing-Li L-2.png
Scientific Editor Work List	84149-Scientific editor work list.pdf
CrossCheck Report	84149-CrossCheck report.pdf
CrossCheck Report	84149-CrossCheck.png