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7/26/2023 12:10:53 PM | Browse: 131 | Download: 422
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Received |
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2023-06-09 18:32 |
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Peer-Review Started |
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2023-06-09 18:35 |
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To Make the First Decision |
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Return for Revision |
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2023-06-14 01:45 |
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Revised |
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2023-06-27 22:20 |
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Second Decision |
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2023-07-11 02:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-07-11 08:26 |
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Articles in Press |
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2023-07-11 08:26 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-07-09 13:47 |
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Typeset the Manuscript |
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2023-07-19 13:26 |
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Publish the Manuscript Online |
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2023-07-26 11:55 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Christopher J Martoni, Shalini Srivastava, Anders Damholt and Gregory J Leyer |
| Funding Agency and Grant Number |
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| Corresponding Author |
Christopher J Martoni, PhD, Senior Scientist, Clinical Development, Human Health, Chr. Hansen A/S, 10-12 Boege Alle, Hoersholm 2970, Denmark. cachma@chr-hansen.com |
| Key Words |
Randomized clinical trial; Diarrhea-predominant irritable bowel syndrome; Microbiome; Probiotic; Lactiplantibacillus plantarum |
| Core Tip |
The current study is unique in its dose-ranging assessment of a Lactiplantibacillus plantarum (L. plantarum) probiotic strain in a well-powered multi-center randomized controlled trial in adults with diarrhea-predominant irritable bowel syndrome (IBS-D). L. plantarum Lpla33 (DSM34428) was well tolerated and significantly improved global IBS symptom scores as compared to placebo, both at an absolute level and in the number of clinically relevant responders. Further, a dose-ranging effect was observed in global IBS symptom scores, abdominal pain severity, quality of life, and normalization of diarrheal stool type. |
| Publish Date |
2023-07-26 11:55 |
| Citation |
Martoni CJ, Srivastava S, Damholt A, Leyer GJ. Efficacy and dose response of Lactiplantibacillus plantarum in diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2023; 29(28): 4451-4465 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i28/4451.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i28.4451 |
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