Publication Name	World Journal of Clinical Cases
Manuscript ID	87521
Country	India

Received	2023-08-17 07:45
Peer-Review Started	2023-08-17 07:45
To Make the First Decision
Return for Revision	2023-09-04 02:53
Revised	2023-09-12 12:22
Second Decision	2023-09-18 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-09-18 08:33
Articles in Press	2023-09-18 08:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-25 07:12
Publish the Manuscript Online	2023-10-13 14:28

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Ophthalmology
Manuscript Type	Retrospective Study
Article Title	Axenfeld-Reiger syndrome: A search for the missing links
Manuscript Source	Invited Manuscript
All Author List	Arvind Kumar Morya, Prasanna Venkatesh Ramesh, Sony Sinha, Prateek Nishant, Nazia Nain, Ravi Naik Ramavath, Chetana Gone and Ripunjay Prasad
Funding Agency and Grant Number
Corresponding Author	Arvind Kumar Morya, MBBS, MNAMS, MS, Additional Professor, Department of Ophthalmology, All India Institute of Medical Sciences, Bibi Nagar, Hyderabad 508126, Telangana, India. bulbul.morya@gmail.com
Key Words	Axenfeld-Reiger Syndrome; Glaucoma; Limbal stem cell deficiency; Vernal keratoconjuctivitis
Core Tip	Clinical characteristic of Axenfeld-Rieger syndrome (ARS) is well defined and approximately 50% develop glaucoma later in life. Despite significant progress in unraveling the genetic basis of ARS, many questions still remain unanswered. One of the key challenges in studying this syndrome is the wide variability in clinical presentation, even among individuals with the same underlying genetic mutation. This suggests the involvement of additional genetic and environmental factors that modulate the phenotypic expression of the syndrome. Researchers are actively exploring epigenetic modifications, gene-gene interactions, and gene-environment interactions to uncover these missing links.
Publish Date	2023-10-13 14:28
Citation	Morya AK, Ramesh PV, Sinha S, Nishant P, Nain N, Ramavath RN, Gone C, Prasad R. Axenfeld-reiger syndrome: A search for the missing links. World J Clin Cases 2023; 11(29): 7034-7042
URL	https://www.wjgnet.com/2307-8960/full/v11/i29/7034.htm
DOI	https://dx.doi.org/10.12998/wjcc.v11.i29.7034

Full Article (PDF)	WJCC-11-7034-with-cover.pdf
Full Article (Word)	WJCC-11-7034.docx
Manuscript File	87521_Auto_Edited-LJH-JLW.docx
Answering Reviewers	87521-Answering reviewers.pdf
Audio Core Tip	87521-Audio core tip.mov
Biostatistics Review Certificate	87521-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	87521-Conflict-of-interest statement.pdf
Copyright License Agreement	87521-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	87521-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	87521-Language certificate.pdf
Video	87521-Video.mp4
Peer-review Report	87521-Peer-review(s).pdf
Scientific Misconduct Check	87521-Bing-Liu JH-2.png
Scientific Misconduct Check	87521-CrossCheck.png
Scientific Editor Work List	87521-Scientific editor work list.pdf
CrossCheck Report	87521-CrossCheck report.pdf