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3/28/2024 4:00:35 PM | Browse: 92 | Download: 188
Publication Name World Journal of Gastroenterology
Manuscript ID 91254
Country China
2023-12-26 06:35
Peer-Review Started
2023-12-26 06:35
To Make the First Decision
Return for Revision
2024-01-30 21:05
2024-02-11 15:42
Second Decision
2024-03-05 02:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2024-03-05 05:44
Articles in Press
2024-03-05 05:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2024-03-22 07:23
Publish the Manuscript Online
2024-03-28 12:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Clinical Trials Study
Article Title Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
Manuscript Source Unsolicited Manuscript
All Author List Ting Yang, Kang Chao, Xia Zhu, Xue-Ding Wang, Sumyuet Chan, Yan-Ping Guan, Jing Mao, Pan Li, Shao-Xing Guan, Wen Xie, Xiang Gao and Min Huang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 82020108031, 81973398, 82104290
Guangdong Provincial Key Laboratory of Construction Foundation 2020B1212060034
Guangdong Basic and Applied Basic Research Foundation 2022A1515012549, 2023A1515012667
Corresponding Author Min Huang, PhD, Professor, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, Guangdong Province, China. huangmin@mail.sysu.edu.cn
Key Words Thiopurine-induced late leucopenia; DNA-thioguanine; 6-thioguanine nucleotide; Proactive therapeutic drug monitoring; Crohn’s disease
Core Tip This study pioneeringly explores if early proactive monitoring of DNA-thioguanine (DNATG) or 6-thioguanine nucleotides stable concentration within two months could predict late leucopenia susceptible population under a nudix hydrolase 15 (NUDT15) genotype-guided thiopurines dosing strategy in patients with Crohn’s disease. We first provide evidence indicating that early proactive monitoring of DNATG during the initial stages of thiopurine therapy could be an effective strategy to discern patients susceptible to developing late leukopenia, especially in NUDT15/thiopurine methyltransferase normal metabolizers, with a concentration threshold of 315.72 fmol/μg DNA.
Publish Date 2024-03-28 12:17
Citation Yang T, Chao K, Zhu X, Wang XD, Chan S, Guan YP, Mao J, Li P, Guan SX, Xie W, Gao X, Huang M. Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers. World J Gastroenterol 2024; 30(12): 1751-1763
URL https://www.wjgnet.com/1007-9327/full/v30/i12/1751.htm
DOI https://dx.doi.org/10.3748/wjg.v30.i12.1751
Full Article (PDF) WJG-30-1751-with-cover.pdf
CONSORT 2010 Statement 91254-CONSORT 2010 statement.pdf
Manuscript File 91254_Auto_Edited-YJP.docx
Answering Reviewers 91254-Answering reviewers.pdf
Audio Core Tip 91254-Audio core tip.mp3
Biostatistics Review Certificate 91254-Biostatistics statement.pdf
Clinical Trial Registration Statement 91254-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 91254-Conflict-of-interest statement.pdf
Copyright License Agreement 91254-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 91254-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 91254-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 91254-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 91254-Language certificate.pdf
Supplementary Material 91254-Supplementary material.pdf
Peer-review Report 91254-Peer-review(s).pdf
Scientific Misconduct Check 91254-Bing-Wang JJ-2.png
Scientific Editor Work List 91254-Scientific editor work list.pdf