Publication Name	World Journal of Gastroenterology
Manuscript ID	91254
Country	China

Received	2023-12-26 06:35
Peer-Review Started	2023-12-26 06:35
First Decision by Editorial Office Director	2024-01-30 21:05
Return for Revision	2024-01-30 21:05
Revised	2024-02-11 15:42
Publication Fee Transferred
Second Decision by Editor	2024-03-05 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2024-03-05 05:44
Articles in Press	2024-03-05 05:44
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-22 07:23
Publish the Manuscript Online	2024-03-28 12:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Clinical Trials Study
Article Title	Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
Manuscript Source	Unsolicited Manuscript
All Author List	Ting Yang, Kang Chao, Xia Zhu, Xue-Ding Wang, Sumyuet Chan, Yan-Ping Guan, Jing Mao, Pan Li, Shao-Xing Guan, Wen Xie, Xiang Gao and Min Huang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82020108031, 81973398, 82104290 Guangdong Provincial Key Laboratory of Construction Foundation 2020B1212060034 Guangdong Basic and Applied Basic Research Foundation 2022A1515012549, 2023A1515012667
Corresponding Author	Min Huang, PhD, Professor, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, Guangdong Province, China. huangmin@mail.sysu.edu.cn
Key Words	Thiopurine-induced late leucopenia; DNA-thioguanine; 6-thioguanine nucleotide; Proactive therapeutic drug monitoring; Crohn’s disease
Core Tip	This study pioneeringly explores if early proactive monitoring of DNA-thioguanine (DNATG) or 6-thioguanine nucleotides stable concentration within two months could predict late leucopenia susceptible population under a nudix hydrolase 15 (NUDT15) genotype-guided thiopurines dosing strategy in patients with Crohn’s disease. We first provide evidence indicating that early proactive monitoring of DNATG during the initial stages of thiopurine therapy could be an effective strategy to discern patients susceptible to developing late leukopenia, especially in NUDT15/thiopurine methyltransferase normal metabolizers, with a concentration threshold of 315.72 fmol/μg DNA.
Publish Date	2024-03-28 12:17
Citation	Yang T, Chao K, Zhu X, Wang XD, Chan S, Guan YP, Mao J, Li P, Guan SX, Xie W, Gao X, Huang M. Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers. World J Gastroenterol 2024; 30(12): 1751-1763
URL	https://www.wjgnet.com/1007-9327/full/v30/i12/1751.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i12.1751

Full Article (PDF)	WJG-30-1751-with-cover.pdf