| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ting Yang, Kang Chao, Xia Zhu, Xue-Ding Wang, Sumyuet Chan, Yan-Ping Guan, Jing Mao, Pan Li, Shao-Xing Guan, Wen Xie, Xiang Gao and Min Huang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82020108031, 81973398, 82104290 |
| Guangdong Provincial Key Laboratory of Construction Foundation |
2020B1212060034 |
| Guangdong Basic and Applied Basic Research Foundation |
2022A1515012549, 2023A1515012667 |
|
| Corresponding Author |
Min Huang, PhD, Professor, School of Pharmaceutical Sciences, Sun Yat-sen University, No. 132 East Outer Ring Road, Guangzhou Higher Education Mega Center, Guangzhou 510006, Guangdong Province, China. huangmin@mail.sysu.edu.cn |
| Key Words |
Thiopurine-induced late leucopenia; DNA-thioguanine; 6-thioguanine nucleotide; Proactive therapeutic drug monitoring; Crohn’s disease |
| Core Tip |
This study pioneeringly explores if early proactive monitoring of DNA-thioguanine (DNATG) or 6-thioguanine nucleotides stable concentration within two months could predict late leucopenia susceptible population under a nudix hydrolase 15 (NUDT15) genotype-guided thiopurines dosing strategy in patients with Crohn’s disease. We first provide evidence indicating that early proactive monitoring of DNATG during the initial stages of thiopurine therapy could be an effective strategy to discern patients susceptible to developing late leukopenia, especially in NUDT15/thiopurine methyltransferase normal metabolizers, with a concentration threshold of 315.72 fmol/μg DNA. |
| Publish Date |
2024-03-28 12:17 |
| Citation |
Yang T, Chao K, Zhu X, Wang XD, Chan S, Guan YP, Mao J, Li P, Guan SX, Xie W, Gao X, Huang M. Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers. World J Gastroenterol 2024; 30(12): 1751-1763 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i12/1751.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i12.1751 |
